P64209
Gene name |
folE |
Protein name |
GTP cyclohydrolase 1 |
Names |
GTP cyclohydrolase I, GTP-CH-I |
Species |
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
KEGG Pathway |
stm:STM2193 |
EC number |
3.5.4.16: In cyclic amidines |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P64209
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P64209-F1 | Predicted | AlphaFoldDB |
No variants for P64209
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P64209 | |||||
No associated diseases with P64209
3 regional properties for P64209
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | GTP cyclohydrolase I, conserved site | 98 - 114 | IPR018234-1 |
| conserved_site | GTP cyclohydrolase I, conserved site | 146 - 156 | IPR018234-2 |
| domain | GTP cyclohydrolase I domain | 41 - 218 | IPR020602 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.4.16 | In cyclic amidines |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTP cyclohydrolase I activity | Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| 7,8-dihydroneopterin 3'-triphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| tetrahydrobiopterin biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. |
| tetrahydrofolate biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSLSKEAAL | VHDALVARGL | ETPLRPPMDE | LDNETRKSLI | AGHMTEIMQL | LNLDLSDDSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| METPHRIAKM | YVDEIFAGLD | YANFPKITLI | ENKMKVDEMV | TVRDITLTST | CEHHFVTIDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KATVAYIPKD | SVIGLSKINR | IVQFFAQRPQ | VQERLTQQIL | TALQTLLGTN | NVAVSIDAVH |
| 190 | 200 | 210 | 220 | ||
| YCVKARGIRD | ATSATTTTSL | GGLFKSSQNT | RQEFLRAVRH | HP |