P63802
Gene name |
cls (MW2011) |
Protein name |
Cardiolipin synthase |
Names |
CL synthase |
Species |
Staphylococcus aureus (strain MW2) |
KEGG Pathway |
sam:MW2011 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P63802
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P63802-F1 | Predicted | AlphaFoldDB |
No variants for P63802
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P63802 | |||||
No associated diseases with P63802
5 regional properties for P63802
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phospholipase D/Transphosphatidylase | 229 - 256 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 407 - 434 | IPR001736-2 |
| domain | Phospholipase D-like domain | 146 - 274 | IPR025202-1 |
| domain | Phospholipase D-like domain | 335 - 460 | IPR025202-2 |
| domain | Cardiolipin synthase N-terminal | 25 - 68 | IPR027379 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cardiolipin synthase activity | Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiolipin biosynthetic process | The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIELLSIALK | HSNIILNSIF | IGAFILNLLF | AFTIIFMERR | SANSIWAWLL | VLVFLPLFGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILYLLLGRQI | QRDQIFKIDK | EDKKGLELIV | DEQLAALKNE | NFSNSNYQIV | KFKEMIQMLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YNNAAFLTTD | NDLKIYTDGQ | EKFDDLIQDI | RNATDYIHFQ | YYIIQNDELG | RTILNELGKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AEQGVEVKIL | YDDMGSRGLR | KKGLRPFRNK | GGHAEAFFPS | KLPLINLRMN | NRNHRKIVVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGQIGYVGGF | NVGDEYLGKS | KKFGYWRDTH | LRIVGDAVNA | LQLRFILDWN | SQATRDHISY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DDRYFPDVNS | GGTIGVQIAS | SGPDEEWEQI | KYGYLKMISS | AKKSIYIQSP | YFIPDQAFLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SIKIAALGGV | DVNIMIPNKP | DHPFVFWATL | KNAASLLDAG | VKVFHYDNGF | LHSKTLVIDD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EIASVGTANM | DHRSFTLNFE | VNAFIYDQQI | AKKLKQAFID | DLAVSSELTK | ARYAKRSLWI |
| 490 | |||||
| KFKEGISQLL | SPIL |