P63325

PR
Gene name
Rps10
Protein name
40S ribosomal protein S10
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67097
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-165 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P63325

Entry ID Method Resolution Chain Position Source
7CPU EM 282 A SK 1-165 PDB
7CPV EM 303 A SK 1-165 PDB
7LS1 EM 330 A v2 1-165 PDB
7LS2 EM 310 A v2 1-165 PDB
AF-P63325-F1 Predicted AlphaFoldDB

3 variants for P63325

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389426080 124 R>I No EVA
rs3389445476 155 G>D No EVA
rs3389448624 160 R>C No EVA

No associated diseases with P63325

1 regional properties for P63325

Type Name Position InterPro Accession
domain Plectin/S10, N-terminal 3 - 97 IPR005326

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Localized in the granular component (GC) region of the nucleolus
  • Methylation is required for its localization in the GC region
  • Colocalizes with NPS1 in the GC region of the nucleolus (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic ribosome A ribosome located in the cytosol.
cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

3 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46783 RPS10 40S ribosomal protein S10 Homo sapiens (Human) PR
P63326 Rps10 40S ribosomal protein S10 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE
70 80 90 100 110 120
QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE TGRPRPKGPE GERPARFTRG
130 140 150 160
EADRDTYRRS AVPPGADKKA EAGAGSATEF QFRGGFGRGR GQPPQ