P62932
Gene name |
Fbxo40 |
Protein name |
F-box only protein 40 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:207215 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P62932
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P62932-F1 | Predicted | AlphaFoldDB |
34 variants for P62932
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs215470523 | 4 | A>V | No | EVA | |
| rs258156538 | 5 | R>H | No | EVA | |
| rs225732051 | 19 | F>I | No | EVA | |
| rs3389364710 | 47 | H>Q | No | EVA | |
| rs3389415274 | 48 | M>L | No | EVA | |
| rs3389396133 | 59 | P>L | No | EVA | |
| rs260385253 | 82 | A>S | No | EVA | |
| rs3389415238 | 87 | V>L | No | EVA | |
| rs3389415239 | 131 | L>I | No | EVA | |
| rs3389410446 | 134 | Q>H | No | EVA | |
| rs3389331966 | 138 | F>L | No | EVA | |
| rs3389410394 | 175 | G>E | No | EVA | |
| rs3389418252 | 206 | K>N | No | EVA | |
| rs1133083383 | 301 | T>A | No | EVA | |
| rs221974714 | 386 | I>V | No | EVA | |
| rs3389414356 | 415 | S>T | No | EVA | |
| rs3405893300 | 436 | P>S | No | EVA | |
| rs3389408867 | 476 | A>V | No | EVA | |
| rs3389408872 | 491 | P>S | No | EVA | |
| rs3389410400 | 508 | W>* | No | EVA | |
| rs3406786792 | 520 | C>Y | No | EVA | |
| rs3389396070 | 531 | G>E | No | EVA | |
| rs3389410452 | 558 | K>E | No | EVA | |
| rs48248056 | 562 | D>N | No | EVA | |
| rs3389432463 | 562 | D>V | No | EVA | |
| rs3389410474 | 594 | S>T | No | EVA | |
| rs3389410382 | 599 | S>Y | No | EVA | |
| rs47123629 | 621 | S>L | No | EVA | |
| rs3389415291 | 625 | K>N | No | EVA | |
| rs3389396073 | 644 | F>Y | No | EVA | |
| rs234078659 | 652 | N>K | No | EVA | |
| rs47854722 | 676 | R>Q | No | EVA | |
| rs3389396087 | 682 | R>S | No | EVA | |
| rs3389425784 | 689 | P>H | No | EVA |
No associated diseases with P62932
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| muscle cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UH90 | FBXO40 | F-box only protein 40 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRARKPPPA | LHRHCEGCFN | RHCHVPVEPS | VSCLVISCHL | LCGATFHMCK | ESEHTLLCPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EQVPCLNSEY | GCPLSMARHK | LAKHLQVCPA | SVVCCSMEWI | RWPNVDSETF | LHENIMKETP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEECLDTALA | LQDQKVLFRS | LKMVELFPET | RDATEEEPDM | NGDTSWEETG | GAVGGVDARL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APNSCLPATS | RQMMELSQEE | RDALAKTKEG | MDLDKFGKWE | SMFSKEHAAS | VLTGSLGKSE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DKNGDVAGKE | QCSSNVRIGD | AEGSAERRGP | QESQKSQELP | ATMEMTGLAP | WQDGVLERLK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TAVDAKDYNM | YLVHNGRMLI | HFGQMPACTP | KERDFVYGNL | EAQEVKTVYT | FKIPVSYCGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RARLGDAMLK | CRPSEHKAVD | TSDLGISVED | LPKSDLIKTT | LQCALERELK | GHVISESRSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DGLFMDLATQ | TYNFEPEQFS | SETVLADLLG | TAQPGGLHVE | LHSECVTRRH | NKSSSAFTFT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CNKFFRRDEF | PLHFKNVHTD | IQSSLDGWFQ | HRCPLAYLGC | TFVQNHFRPP | GQKAKVIYSQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELKTFAIKPE | VAPELSEKWK | SDHLSGRDGK | SLNSLTSLPL | EVLQYIAGFL | DSISLSQLSQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VSVLMRNICA | TLLQERGMVL | SQWKKKRYSH | GGTSWKVHNQ | IWQFSSLFSK | INSWEFNDVT |
| 670 | 680 | 690 | 700 | ||
| SMSEHLKTCP | FNIVERKTDP | IRLTSMCQPQ | EKARESLVST | FRARPRGRHF |