P62685

PR
Gene name
ERVK-8
Protein name
Endogenous retrovirus group K member 8 Gag polyprotein
Names
HERV-K115 Gag protein, HERV-K_8p23.1 provirus ancestral Gag polyprotein, Gag polyprotein
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

564-645 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P62685

Entry ID Method Resolution Chain Position Source
AF-P62685-F1 Predicted AlphaFoldDB

No variants for P62685

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P62685

No associated diseases with P62685

3 regional properties for P62685

Type Name Position InterPro Accession
domain eRF1 domain 1/Pelota-like 3 - 139 IPR005140
domain eRF1 domain 2 143 - 276 IPR005141
domain eRF1 domain 3 280 - 417 IPR005142

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Lipid-anchor
  • Cytoplasmic membrane (in a transfection system)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
nucleic acid binding Binding to a nucleic acid.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
viral process A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGQTKSKIKS KYASYLSFIK ILLKRGGVKV STKNLIKLFQ IIEQFCPWFP EQGTLDLKDW
70 80 90 100 110 120
KRIGKELKQA GRKGNIIPLT VWNDWAIIKA ALEPFQTEED SISVSDAPGS CLIDCNENTR
130 140 150 160 170 180
KKSQKETESL HCEYVAEPVM AQSTQNVDYN QLQEVIYPET LKLEGKGPEL VGPSESKPRG
190 200 210 220 230 240
TSPLPAGQVP VTLQPQKQVK ENKTQPPVAY QYWPPAELQY RPPPESQYGY PGMPPAPQGR
250 260 270 280 290 300
EPYPQPPTRR LNPTAPPSRQ GSELHEIIDK SRKEGDTEAW QFPVTLEPMP PGEGAQEGEP
310 320 330 340 350 360
PTVEARYKSF SIKMLKDMKE GVKQYGPNSP YMRTLLDSIA HGHRLIPYDW EILAKSSLSP
370 380 390 400 410 420
SQFLQFKTWW IDGVQEQVRR NRAANPPVNI DADQLLGIGQ NWSTISQQAL MQNEAIEQVR
430 440 450 460 470 480
AICLRAWEKI QDPGSTCPSF NTVRQGSKEP YPDFVARLQD VAQKSIADEK ARKVIVELMA
490 500 510 520 530 540
YENANPECQS AIKPLKGKVP AGSDVISEYV KACDGIGGAM HKAMLMAQAI TGVVLGGQVR
550 560 570 580 590 600
TFGGKCYNCG QIGHLKKNCP VLNKQNITIQ ATTTGREPPD LCPRCKKGKH WASQCRSKFD
610 620 630 640
KNGQPLSGNE QRGQPQAPQQ TGAFPIQPFV PQGFQDNNPH CPKCFRE