P62374

PR
Gene name
hisS
Protein name
Histidine--tRNA ligase
Names
Histidyl-tRNA synthetase, HisRS
Species
Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
KEGG Pathway
tth:TT_C0360
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

162-237 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P62374

Entry ID Method Resolution Chain Position Source
1H4V X-ray 240 A B 1-421 PDB
4RDX X-ray 255 A A 1-421 PDB
AF-P62374-F1 Predicted AlphaFoldDB

No variants for P62374

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P62374

No associated diseases with P62374

3 regional properties for P62374

Type Name Position InterPro Accession
domain Anticodon-binding 331 - 417 IPR004154
domain Aminoacyl-tRNA synthetase, class II 1 - 324 IPR006195
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 8 - 317 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTARAVRGTK DLFGKELRMH QRIVATARKV LEAAGALELV TPIFEETQVF EKGVGAATDI
70 80 90 100 110 120
VRKEMFTFQD RGGRSLTLRP EGTAAMVRAY LEHGMKVWPQ PVRLWMAGPM FRAERPQKGR
130 140 150 160 170 180
YRQFHQVNYE ALGSENPILD AEAVVLLYEC LKELGLRRLK VKLSSVGDPE DRARYNAYLR
190 200 210 220 230 240
EVLSPHREAL SEDSKERLEL NPMRILDSKS ERDQALLKEL GVRPMLDFLG EEARAHLKEV
250 260 270 280 290 300
ERHLERLSVP YELEPALVRG LDYYVRTAFE VHHEEIGAQS ALGGGGRYDG LSELLGGPRV
310 320 330 340 350 360
PGVGFAFGVE RVALALEAEG FGLPEEKGPD LYLIPLTEEA VAEAFYLAEA LRPRLRAEYA
370 380 390 400 410 420
LAPRKPAKGL EEALKRGAAF AGFLGEDELR AGEVTLKRLA TGEQVRLSRE EVPGYLLQAL
G