P62350

PR
Gene name
hisI
Protein name
Histidine biosynthesis bifunctional protein HisIE
Names
Species
Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
KEGG Pathway
tth:TT_C1080
EC number
3.5.4.19: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P62350

Entry ID Method Resolution Chain Position Source
AF-P62350-F1 Predicted AlphaFoldDB

No variants for P62350

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P62350

No associated diseases with P62350

1 regional properties for P62350

Type Name Position InterPro Accession
domain Phosphoribosyl-AMP cyclohydrolase domain 29 - 101 IPR002496

Functions

Description
EC Number 3.5.4.19 In cyclic amidines
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosyl-AMP cyclohydrolase activity Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.
phosphoribosyl-ATP diphosphatase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+).

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDLSAVRFDE KGLVPVVVQD ARTGEVLTLA YANREALEET LRTRRSTFFS RSRQALWRKG
70 80 90 100 110 120
ETSGHTQEVV EVLLDCDGDA VVYRVLPQGP ACHTGERTCF HRALLEGEKD LGFVVGQVYA
130 140 150 160 170 180
TIKERLRTLP EGSYVARMHH AGLDRILKKI GEEAGEVILA AKNQNPEELR HEAADLLFHL
190 200 210
LLTLAELGLT PEDLAKTLWE RHRPRSPYDG SHGN