AiPD: Autoinhibited Protein Database

P62174

Gene name	glnR
Protein name	HTH-type transcriptional regulator GlnR
Names
Species	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
KEGG Pathway	bce:BC3706
EC number
Protein Class

Descriptions

GlnR is a repressor that regulates gene expression in response to changes in nitrogen availability. The C-terminal autoinhibitory region impedes the dimerization of GlnR and consequently prevents the binding of GlnR N-terminal domain to DNA.

Autoinhibitory domains (AIDs)

92-117 (C-terminal autoinhibitory region) SS

Target domain	10-79 (DNA-binding domain)
Relief mechanism	Partner binding
Assay

AID

92-117 (C-terminal autoinhibitory region)

Target domain

10-79 (DNA-binding domain)

Relief mechanism

Partner binding (Structural rearrangement of C-terminal region by FBI-GS)

Assay

Accessory elements

No accessory elements

References

Wray LV Jr et al. (2008) "Bacillus subtilis GlnR contains an autoinhibitory C-terminal domain required for the interaction with glutamine synthetase", Molecular microbiology, 68, 277-85

Autoinhibited structure

Activated structure

1 structures for P62174

Entry ID	Method	Resolution	Chain	Position	Source
AF-P62174-F1	Predicted				AlphaFoldDB

No variants for P62174

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P62174

No associated diseases with P62174

1 regional properties for P62174

Type	Name	Position	InterPro Accession
domain	MerR-type HTH domain	10 - 79	IPR000551

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

1 GO annotations of biological process

Name	Definition
regulation of transcription, DNA-templated	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MKEDRRSAPL	FPIGIVMDLT	QLSARQIRYY	EEHNLVSPTR	TKGNRRLFSF	NDVDKLLEIK
70	80	90	100	110	120
DLLDQGLNMA	GIKQVLLMKE	NQTEAVKVKE	ETKEISKTEL	RKILRDELQH	TGRFNRTSLR

QGDISRFFH