P61946
Gene name |
metK |
Protein name |
S-adenosylmethionine synthase |
Names |
AdoMet synthase, MAT, Methionine adenosyltransferase |
Species |
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) |
KEGG Pathway |
gsu:GSU1880 |
EC number |
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P61946
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P61946-F1 | Predicted | AlphaFoldDB |
No variants for P61946
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P61946 | |||||
No associated diseases with P61946
5 regional properties for P61946
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 2 - 241 | IPR003439 |
| domain | AAA+ ATPase domain | 30 - 218 | IPR003593 |
| conserved_site | ABC transporter-like, conserved site | 141 - 155 | IPR017871 |
| domain | NIL domain | 265 - 340 | IPR018449 |
| domain | Methionine import ATP-binding protein MetN, ATP-binding domain | 1 - 233 | IPR041701 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.6 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| methionine adenosyltransferase activity | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| S-adenosylmethionine biosynthetic process | The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMKDYIFTS | ESVSEGHPDK | VADQVSDAIL | DAILTQDKRA | RVACETLVTT | GMAVIAGEIT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTAVVDYPKV | VRETIKEIGY | NDSAMGFDWE | TCAVLVSIDK | QSPDISQGVT | EGEGMFKEQG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGDQGLMFGY | ACNETPELMP | MTIMYSHRLT | QKLAEVRKNG | TLDFLRPDSK | SQVSIQYVDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RPVRVDTVVI | SSQHTPEVSY | ETIKEGIIEE | VVKKIIPVEL | MDDKTRFLIN | PTGRFVIGGP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MGDCGLTGRK | IIVDSYGGHG | AHGGGAFSGK | DPSKVDRSAA | YMGRYVAKNL | VAAGLCERCE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VQVAYAIGVA | EPVSVMVDTA | GTGKIPSARI | AEIIREVFDL | RPRAIIEQLD | LLRPIYRKTA |
| 370 | 380 | ||||
| AYGHFGRELP | EFTWERTDKI | DIIRQKAGI |