P61705

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) (Mycobacterium paratuberculosis)
KEGG Pathway
mpa:MAP_1077
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

348-477 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P61705

Entry ID Method Resolution Chain Position Source
AF-P61705-F1 Predicted AlphaFoldDB

No variants for P61705

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P61705

No associated diseases with P61705

4 regional properties for P61705

Type Name Position InterPro Accession
domain DHHA1 domain 750 - 892 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 669 - 713 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 571 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 726 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQTHEIRKRF LDHFVKAGHT EVPSASVILD DPNLLFVNAG MVQFVPYFLG ARTPPYPTAT
70 80 90 100 110 120
SIQKCIRTPD IDEVGITTRH NTFFQMAGNF SFGDYFKREA IELAWTLLTG SVEQGGYGLD
130 140 150 160 170 180
PERIWTTVYF DDDEAVRLWQ EIAGLPAERI QRRGMEDNYW SMGIPGPCGP SSEIYYDRGE
190 200 210 220 230 240
EFGVGGGPIA NEDRYVELWN LVFMQSERGE GTSKTDFEIL GPLPRKNIDT GMGVERVAFV
250 260 270 280 290 300
LQGVHNVYET DLLRPVIDAV AARAPRPYDA GNHDDDVRYR IIADHSRTAA ILIGDGVTPG
310 320 330 340 350 360
NDGRGYVLRR LLRRVIRSAR LLDIEGPIVG DLMATVRDAM GPSYPELVTD FDRIARIAVA
370 380 390 400 410 420
EETAFNRTLA AGSKLFDEVA STTKATGAKS ISGSDAFTLH DTYGFPIELT LEMASEAGLQ
430 440 450 460 470 480
VDEVGFRELM AEQRRRAKAD AAARKHAHAD LTAYRELVDA GPTEFTGFDE LSSEARILGI
490 500 510 520 530 540
FVDGKRVPVV THGGDGADRV ELVLDRTPLY AESGGQIADE GTISGTGAGE SARAAVTDVQ
550 560 570 580 590 600
KIAKTLWVHR VNVESGEFVE GDTVIAAVDP QWRRGATQGH SGTHMVHAAL RQVLGPNAVQ
610 620 630 640 650 660
AGSLNRPGYL RFDFNWQGPL TEEQRTQIEE VTNQAVQADF EVHTFTEQLE KAKAMGAIAL
670 680 690 700 710 720
FGESYPEQVR VVEIGGPFSL ELCGGTHVHN SAQIGPVTIL GESSVGSGVR RVEAYVGLDS
730 740 750 760 770 780
FRHLAKERAL MAGLASSLKV PSEEVPARVA NLVERLRAAE KELERMRLAS ARAAAGNAAA
790 800 810 820 830 840
GAERIGNVRV VAQRMSGGMT AADLRSLVGD IRGKLGSDPA VVALIAEGEG GSVPYAVAAN
850 860 870 880 890
PAAQDLGIRA NDLVKQLAAP VDGRGGGKAD LAQGSGKDPA GIDAALDAVR SEIAAIARVG