P61677

PR
Gene name
murC
Protein name
UDP-N-acetylmuramate--L-alanine ligase
Names
UDP-N-acetylmuramoyl-L-alanine synthetase
Species
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
KEGG Pathway
cdi:DIP1597
EC number
6.3.2.8: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

42-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P61677

Entry ID Method Resolution Chain Position Source
AF-P61677-F1 Predicted AlphaFoldDB

No variants for P61677

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P61677

No associated diseases with P61677

3 regional properties for P61677

Type Name Position InterPro Accession
domain FAD linked oxidase, N-terminal 35 - 164 IPR006094
domain UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal 199 - 297 IPR011601
domain FAD-binding domain, PCMH-type 30 - 194 IPR016166

Functions

Description
EC Number 6.3.2.8 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
UDP-N-acetylmuramate-L-alanine ligase activity Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
regulation of cell shape Any process that modulates the surface configuration of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNSIDLSRVH MIGIGGAGMS GVARILLSCG SVVSGSDVKE SRPVAALRAM GATIAVGHKA
70 80 90 100 110 120
ENLAISGSMP TVVVTSFAAI PQDNPELQEA RANNIPVIRR SDLLGELMED HQQVLIAGTH
130 140 150 160 170 180
GKTSTTSMAV VALQAAGKDP SFAIGGQLNK AGTNAHDGTG KAFVAEADES DASLLRYKPD
190 200 210 220 230 240
IAVVTNIEPD HLDFFKTSEA YFKVFDDFAE RVQPGGTLVV CLDDPHAAAL GEKFKDRMTV
250 260 270 280 290 300
RGYGSPAAAQ QYPDVAFTVV EHMEVGPAGT RARITVGDDT VDVIMRIPGH HMVLNACAAL
310 320 330 340 350 360
TAGVTAGAEL ERLAAGISDF SGVRRRFEFH GRVSGGAFHD AEVYDDYAHH PTEVTAVLKA
370 380 390 400 410 420
ARQQQEARGI GRVVVAFQPH LYSRTMEFAA EFAEALSLAD HAVILDIFGA REQPVEGVDS
430 440 450 460 470
RIISDKMTIP VVFEPNFSAV AAQVKKIAQP NDIIVTMGAG SVTLLADEIL TALRESE