P60405

PR
Gene name
rplB (TTHA1689)
Protein name
50S ribosomal protein L2
Names
Species
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
KEGG Pathway
ttj:TTHA1689
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

239 structures for P60405

Entry ID Method Resolution Chain Position Source
1VVJ X-ray 344 A RD/YD 1-276 PDB
1VY4 X-ray 260 A BD/DD 1-276 PDB
1VY5 X-ray 255 A BD/DD 1-276 PDB
1VY6 X-ray 290 A BD/DD 1-276 PDB
1VY7 X-ray 280 A BD/DD 1-276 PDB
4L47 X-ray 322 A RD/YD 1-276 PDB
4L71 X-ray 390 A RD/YD 1-276 PDB
4LEL X-ray 390 A RD/YD 1-276 PDB
4LFZ X-ray 392 A RD/YD 1-276 PDB
4LNT X-ray 294 A RD/YD 1-276 PDB
4LSK X-ray 348 A RD/YD 1-276 PDB
4LT8 X-ray 314 A RD/YD 1-276 PDB
4P6F X-ray 360 A RD/YD 1-276 PDB
4P70 X-ray 368 A RD/YD 1-276 PDB
4TUA X-ray 360 A RD/YD 1-276 PDB
4TUB X-ray 360 A RD/YD 1-276 PDB
4TUC X-ray 360 A RD/YD 1-276 PDB
4TUD X-ray 360 A RD/YD 1-276 PDB
4TUE X-ray 350 A RD/YD 1-276 PDB
4V42 X-ray 550 A BD 62-234 PDB
4V4P X-ray 550 A AD 62-234 PDB
4V4X X-ray 500 A BD 1-276 PDB
4V4Y X-ray 550 A BD 1-276 PDB
4V4Z X-ray 451 A BD 1-276 PDB
4V51 X-ray 280 A BD/DD 2-276 PDB
4V5A X-ray 350 A BD/DD 2-276 PDB
4V5C X-ray 330 A BD/DD 1-276 PDB
4V5D X-ray 350 A BD/DD 1-276 PDB
4V5E X-ray 345 A BD/DD 1-276 PDB
4V5F X-ray 360 A BD/DD 1-276 PDB
4V5G X-ray 360 A BD/DD 1-276 PDB
4V5J X-ray 310 A BD/DD 1-276 PDB
4V5K X-ray 320 A BD/DD 1-276 PDB
4V5L X-ray 310 A BD 1-276 PDB
4V5M EM 780 A BD 1-276 PDB
4V5N EM 760 A BD 1-276 PDB
4V5P X-ray 310 A BD/DD 1-276 PDB
4V5Q X-ray 310 A BD/DD 1-276 PDB
4V5R X-ray 310 A BD/DD 1-276 PDB
4V5S X-ray 310 A BD/DD 1-276 PDB
4V68 EM 640 A BD 2-273 PDB
4V6A X-ray 310 A BD/DD 1-276 PDB
4V6F X-ray 310 A AD/DD 1-276 PDB
4V6G X-ray 350 A BD/DD 1-276 PDB
4V7J X-ray 330 A AD/BD 1-276 PDB
4V7K X-ray 360 A AD/BD 1-276 PDB
4V7L X-ray 300 A BD/DD 1-276 PDB
4V7M X-ray 345 A BD/DD 1-276 PDB
4V7W X-ray 300 A BD/DD 1-276 PDB
4V7X X-ray 300 A BD/DD 1-276 PDB
4V7Y X-ray 300 A BD/DD 1-276 PDB
4V7Z X-ray 310 A BD/DD 1-276 PDB
4V87 X-ray 310 A AD/DD 2-273 PDB
4V8A X-ray 320 A AD/BD 1-276 PDB
4V8B X-ray 300 A BD/DD 1-276 PDB
4V8C X-ray 330 A AD/BD 1-276 PDB
4V8D X-ray 300 A BD/DD 1-276 PDB
4V8E X-ray 330 A AD/CD 1-276 PDB
4V8F X-ray 330 A AD/DD 1-276 PDB
4V8G X-ray 300 A BD/DD 1-276 PDB
4V8H X-ray 310 A BD/DD 1-276 PDB
4V8I X-ray 270 A BD/DD 1-276 PDB
4V8J X-ray 390 A BD/DD 1-276 PDB
4V8N X-ray 310 A BD/DD 1-276 PDB
4V8O X-ray 380 A BD 1-276 PDB
4V8Q X-ray 310 A AD 1-276 PDB
4V8U X-ray 370 A BD/DD 1-276 PDB
4V8X X-ray 335 A BD/DD 1-276 PDB
4V90 X-ray 295 A BD 2-276 PDB
4V95 X-ray 320 A BD/DD 1-276 PDB
4V97 X-ray 352 A BD/DD 1-276 PDB
4V9A X-ray 330 A BD/DD 1-276 PDB
4V9B X-ray 310 A BD/DD 1-276 PDB
4V9H X-ray 286 A BD 1-276 PDB
4V9I X-ray 330 A BD/DD 2-272 PDB
4V9R X-ray 300 A BD/DD 1-276 PDB
4V9S X-ray 310 A BD/DD 1-276 PDB
4W2E X-ray 290 A D 1-276 PDB
4W2F X-ray 240 A BD/DD 1-276 PDB
4W2G X-ray 255 A BD/DD 1-276 PDB
4W2H X-ray 270 A BD/DD 1-276 PDB
4W2I X-ray 270 A BD/DD 1-276 PDB
4W4G X-ray 330 A RD/YD 1-276 PDB
4WPO X-ray 280 A AD/CD 1-276 PDB
4WQ1 X-ray 310 A PDB
4WQF X-ray 280 A AD/CD 1-276 PDB
4WQR X-ray 315 A 11/19 1-276 PDB
4WQU X-ray 280 A AD/CD 1-276 PDB
4WQY X-ray 280 A AD/CD 1-276 PDB
4WR6 X-ray 305 A 11/19 1-276 PDB
4WRA X-ray 305 A 11/19 1-276 PDB
4WRO X-ray 305 A 11 1-276 PDB
4WSD X-ray 295 A 11/19 1-276 PDB
4WSM X-ray 330 A 11/19 1-276 PDB
4WT1 X-ray 305 A 11/19 1-276 PDB
4WT8 X-ray 340 A CB/DB 2-272 PDB
4WU1 X-ray 320 A 11/19 1-276 PDB
4WZD X-ray 310 A 11/19 1-276 PDB
4WZO X-ray 330 A 11/19 1-276 PDB
4Y4O X-ray 230 A 1D/2D 1-276 PDB
4Y4P X-ray 250 A 1D/2D 1-276 PDB
4YPB X-ray 340 A RD/YD 1-276 PDB
4YZV X-ray 310 A RD/YD 1-276 PDB
4Z3S X-ray 265 A 1D/2D 1-276 PDB
4Z8C X-ray 290 A 1D/2D 1-276 PDB
4ZER X-ray 310 A 1D/2D 2-276 PDB
4ZSN X-ray 360 A RD/YD 1-276 PDB
5A9Z EM 470 A AD 5-276 PDB
5AA0 EM 500 A AD 5-276 PDB
5CZP X-ray 330 A RD/YD 1-276 PDB
5D8B X-ray 363 A A/WA 2-272 PDB
5DFE X-ray 310 A RD/YD 1-276 PDB
5DOX X-ray 310 A 1D/2D 1-276 PDB
5DOY X-ray 260 A 1D/2D 1-276 PDB
5E7K X-ray 320 A 11/19 1-276 PDB
5E81 X-ray 295 A 11/19 1-276 PDB
5EL4 X-ray 315 A 11/19 1-276 PDB
5EL5 X-ray 315 A 11/19 1-276 PDB
5EL6 X-ray 310 A 11/19 1-276 PDB
5EL7 X-ray 315 A 11/19 1-276 PDB
5F8K X-ray 280 A 1D/2D 2-276 PDB
5FDU X-ray 290 A 1D/2D 2-276 PDB
5FDV X-ray 280 A 1D/2D 2-276 PDB
5HAU X-ray 300 A 1D/2D 1-276 PDB
5HCP X-ray 289 A 1D/2D 1-276 PDB
5HCQ X-ray 280 A 1D/2D 1-276 PDB
5HCR X-ray 280 A 1D/2D 1-276 PDB
5HD1 X-ray 270 A 1D/2D 1-276 PDB
5IB7 X-ray 299 A 11/19 1-276 PDB
5IB8 X-ray 313 A 11/19 1-276 PDB
5IBB X-ray 296 A 11/19 1-276 PDB
5IMQ EM 380 A a 1-276 PDB
5IMR EM - a 1-276 PDB
5J30 X-ray 320 A RD/YD 1-276 PDB
5J3C X-ray 304 A RD/YD 1-276 PDB
5J4B X-ray 260 A 1D/2D 1-276 PDB
5J4C X-ray 280 A 1D/2D 1-276 PDB
5J8B X-ray 260 A D 1-276 PDB
5NDJ X-ray 315 A 11/19 1-276 PDB
5NDK X-ray 295 A 11/19 1-276 PDB
5OT7 EM 380 A g 2-276 PDB
5UQ7 EM 350 A D 2-276 PDB
5UQ8 EM 320 A D 2-276 PDB
5VP2 X-ray 280 A 1D/2D 1-276 PDB
5VPO X-ray 334 A RD/YD 1-276 PDB
5VPP X-ray 390 A RD/YD 1-276 PDB
5W4K X-ray 270 A 1D/2D 1-276 PDB
5WIS X-ray 270 A 1D/2D 1-276 PDB
5WIT X-ray 260 A 1D/2D 1-276 PDB
5ZLU EM 360 A Z 1-276 PDB
6BUW X-ray 350 A RD/YD 1-276 PDB
6BZ6 X-ray 318 A RD/YD 1-276 PDB
6BZ7 X-ray 368 A RD/YD 1-276 PDB
6BZ8 X-ray 374 A RD/YD 1-276 PDB
6C5L X-ray 320 A BD/DD 1-276 PDB
6CAE X-ray 260 A 1D/2D 1-276 PDB
6CFJ X-ray 280 A 1D/2D 1-276 PDB
6CFK X-ray 270 A 1D/2D 1-276 PDB
6CFL X-ray 260 A 1D/2D 1-276 PDB
6CZR X-ray 314 A 1D/2D 2-276 PDB
6FKR X-ray 320 A 1D/2D 2-276 PDB
6GSJ X-ray 296 A 11/19 1-276 PDB
6GSK X-ray 336 A 11/19 1-276 PDB
6GSL X-ray 316 A 11/19 1-276 PDB
6GZQ EM 328 A C1 2-273 PDB
6GZX EM 457 A C1/C2 2-273 PDB
6GZZ EM 413 A C1/C2 2-273 PDB
6N9E X-ray 370 A 1D/2D 1-276 PDB
6N9F X-ray 370 A 1D/2D 1-276 PDB
6ND5 X-ray 260 A 1D/2D 1-276 PDB
6ND6 X-ray 285 A 1D/2D 1-276 PDB
6NDK X-ray 364 A RD/YD 1-276 PDB
6NSH X-ray 340 A RD/YD 1-276 PDB
6NTA X-ray 310 A RD/YD 1-276 PDB
6NUO X-ray 320 A RD/YD 1-276 PDB
6NWY X-ray 350 A RD/YD 1-276 PDB
6O3M X-ray 397 A RD/YD 1-276 PDB
6O97 X-ray 275 A 1D/2D 1-276 PDB
6OF1 X-ray 280 A 1D/2D 1-276 PDB
6OF6 X-ray 320 A RD/YD 1-276 PDB
6OJ2 X-ray 320 A RD/YD 1-276 PDB
6OPE X-ray 310 A RD/YD 1-276 PDB
6ORD X-ray 310 A RD/YD 1-276 PDB
6OSI X-ray 414 A RD/YD 1-276 PDB
6OTR X-ray 312 A RD/YD 1-276 PDB
6OXA X-ray 325 A RD/YD 1-276 PDB
6OXI X-ray 350 A RD/YD 1-276 PDB
6Q95 EM 370 A B 2-273 PDB
6QNQ X-ray 350 A 11/19 1-276 PDB
6QNR X-ray 310 A 11/19 1-276 PDB
6UCQ X-ray 350 A 1D/2D 1-276 PDB
6UO1 X-ray 295 A 1D/2D 1-276 PDB
6XHV X-ray 240 A 1D/2D 1-276 PDB
6XHW X-ray 250 A 1D/2D 1-276 PDB
6XHX X-ray 255 A 1D/2D 1-276 PDB
6XHY X-ray 260 A 1D/2D 1-276 PDB
6XQD X-ray 280 A 1D/2D 1-276 PDB
6XQE X-ray 300 A 1D/2D 1-276 PDB
7AZO X-ray 330 A L2A/L2B 1-276 PDB
7AZS X-ray 310 A L2A/L2B 1-276 PDB
7JQL X-ray 300 A 1D/2D 1-276 PDB
7JQM X-ray 305 A 1D/2D 1-276 PDB
7LH5 X-ray 327 A BD/DD 1-276 PDB
7MD7 X-ray 280 A 1D/2D 1-276 PDB
7RQ8 X-ray 250 A 1D/2D 1-276 PDB
7RQ9 X-ray 260 A 1D/2D 1-276 PDB
7RQA X-ray 240 A 1D/2D 1-276 PDB
7RQB X-ray 245 A 1D/2D 1-276 PDB
7RQC X-ray 250 A 1D/2D 1-276 PDB
7RQD X-ray 250 A 1D/2D 1-276 PDB
7RQE X-ray 240 A 1D/2D 1-276 PDB
7U2H X-ray 255 A 1D/2D 1-276 PDB
7U2I X-ray 255 A 1D/2D 1-276 PDB
7U2J X-ray 255 A 1D/2D 1-276 PDB
8CVJ X-ray 240 A 1D/2D 1-276 PDB
8CVK X-ray 250 A 1D/2D 1-276 PDB
8CVL X-ray 230 A 1D/2D 1-276 PDB
8EKB X-ray 270 A 1D/2D 1-276 PDB
8EV6 X-ray 295 A 1D/2D 1-276 PDB
8EV7 X-ray 289 A 1D/2D 1-276 PDB
8FC1 X-ray 250 A 1D/2D 1-276 PDB
8FC2 X-ray 250 A 1D/2D 1-276 PDB
8FC3 X-ray 260 A 1D/2D 1-276 PDB
8FC4 X-ray 245 A 1D/2D 1-276 PDB
8FC5 X-ray 265 A 1D/2D 1-276 PDB
8FC6 X-ray 235 A 1D/2D 1-276 PDB
8FOM X-ray 358 A RD/YD 1-276 PDB
8FON X-ray 364 A RD/YD 1-276 PDB
8G29 X-ray 255 A 1D/2D 1-276 PDB
8G2A X-ray 245 A 1D/2D 1-276 PDB
8G2B X-ray 255 A 1D/2D 1-276 PDB
8G2C X-ray 265 A 1D/2D 1-276 PDB
8G2D X-ray 270 A 1D/2D 1-276 PDB
8T8B X-ray 265 A 1D/2D 1-276 PDB
8T8C X-ray 260 A 1D/2D 1-276 PDB
8UD6 X-ray 270 A 1D/2D 1-276 PDB
8UD7 X-ray 255 A 1D/2D 1-276 PDB
8UD8 X-ray 260 A 1D/2D 1-276 PDB
AF-P60405-F1 Predicted AlphaFoldDB

No variants for P60405

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P60405

No associated diseases with P60405

3 regional properties for P60405

Type Name Position InterPro Accession
domain Ribosomal Proteins L2, RNA binding domain 42 - 118 IPR022666
domain Ribosomal protein L2, C-terminal 125 - 253 IPR022669
conserved_site Ribosomal protein L2, conserved site 219 - 230 IPR022671

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).

3 GO annotations of molecular function

Name Definition
rRNA binding Binding to a ribosomal RNA.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

1 GO annotations of biological process

Name Definition
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT VRFRGGGHKR
70 80 90 100 110 120
LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG EKRYIIAPDG LQVGQQVVAG
130 140 150 160 170 180
PDAPIQVGNA LPLRFIPVGT VVHAVELEPK KGAKLARAAG TSAQIQGREG DYVILRLPSG
190 200 210 220 230 240
ELRKVHGECY ATVGAVGNAD HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA
250 260 270
PRGRPPASPW GWQTKGLKTR KRRKPSSRFI IARRKK