P59815

PR
Gene name
rluB (SF1271, S1356)
Protein name
Ribosomal large subunit pseudouridine synthase B
Names
23S rRNA pseudouridine(2605) synthase, rRNA pseudouridylate synthase B, rRNA-uridine isomerase B
Species
Shigella flexneri
KEGG Pathway
sfx:S1356
EC number
5.4.99.22: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

211-290 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P59815

Entry ID Method Resolution Chain Position Source
AF-P59815-F1 Predicted AlphaFoldDB

No variants for P59815

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P59815

No associated diseases with P59815

3 regional properties for P59815

Type Name Position InterPro Accession
domain RNA-binding S4 domain 3 - 74 IPR002942
domain Pseudouridine synthase, RsuA/RluA-like 69 - 199 IPR006145
conserved_site Pseudouridine synthase, RsuA/RluB/E/F, conserved site 107 - 121 IPR018496

Functions

Description
EC Number 5.4.99.22 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA pseudouridine synthase activity Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

1 GO annotations of biological process

Name Definition
enzyme-directed rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEKLQKVLA RAGHGSRREI ESIIEAGRVS VDGKIAKLGD RVEVTPGLKI RIDGHLISVR
70 80 90 100 110 120
ESAEQICRVL AYYKPEGELC TRNDPEGRPT VFDRLPKLRG ARWIAVGRLD VNTCGLLLFT
130 140 150 160 170 180
TDGELANRLM HPSREVEREY AVRVFGQVDD AKLRDLSRGV QLEDGPAAFK TIKFSGGEGI
190 200 210 220 230 240
NQWYNVTLTE GRNREVRRLW EAVGVQVSRL IRVRYGDIPL PKGLPRGGWT ELDLAQTNYL
250 260 270 280
RELVELPPET SSKVAVEKDR RRMKANQIRR AVKRHSQVSG SRRSGGRNNG