P59615

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Burkholderia multivorans (strain ATCC 17616 / 249)
KEGG Pathway
bmu:Bmul_0865
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P59615

Entry ID Method Resolution Chain Position Source
AF-P59615-F1 Predicted AlphaFoldDB

No variants for P59615

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P59615

No associated diseases with P59615

3 regional properties for P59615

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 283 - 292 IPR020557
domain Fumarate lyase, N-terminal 15 - 308 IPR022761
domain Argininosuccinate lyase, C-terminal 371 - 443 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSQLHKKGE AWSARFSEPM SELVKRYTSS VFFDKRLALV DIAGSLAHAN MLAAQKIISA
70 80 90 100 110 120
DDLAAIERGM AQIKGEIERG EFEWQLDLED VHLNIEARLT ALIGDAGKRL HTGRSRNDQV
130 140 150 160 170 180
ATDIRLWLRG EIDRIGGLLN DLRGALIDLA EQNADTIMPG FTHLQVAQPV TFGHHLLAYV
190 200 210 220 230 240
EMFSRDAERM RDCRTRVNRL PLGAAALAGT SYPIDRHAVA KSLGFDGICA NSLDAVSDRD
250 260 270 280 290 300
FAIEFTAAAA LVMTHVSRFS EELVLWMSPR VGFIDIADRF CTGSSIMPQK KNPDVPELAR
310 320 330 340 350 360
GKTGRVNGHL MALLTLMKGQ PLAYNKDNQE DKEPLFDTVD TVADTLRIFA EMVAGITVKP
370 380 390 400 410 420
DAMRAAALQG FSTATDLADY LVKRGLPFRD AHEAVAHAVK ICDDRGIDLA DLTLDEMKRE
430 440 450 460
LPNVAQLIGD DVFDYLTLEG SVASRNHPGG TAPDQVRAAA QAARAALGK