P59116
Gene name |
sph2 (LA_1029) |
Protein name |
Sphingomyelinase C 2 |
Names |
Sphingomyelin phosphodiesterase 2, SMase 2 |
Species |
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) |
KEGG Pathway |
lil:LA_1029 |
EC number |
3.1.4.12: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P59116
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P59116-F1 | Predicted | AlphaFoldDB |
No variants for P59116
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P59116 | |||||
No associated diseases with P59116
1 regional properties for P59116
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Endonuclease/exonuclease/phosphatase | 189 - 433 | IPR005135 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.12 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| sphingomyelin phosphodiesterase activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MINKITKPKL | LIGYYLLLFS | LIRCLPEKES | SYKDLFTSLL | FLPNQTNSNQ | VNSVSINNDP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ANPNPVNPAS | ANNNQVNAVP | ENDDPANLNP | VNPASANSNQ | VNAAPENGSP | ADPNPANLAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ANNNQVNAVP | ANNYFTKEDS | SNNIPKKVNS | KNVEIKVLSH | NVFMLPTNLP | RWGNLGHDER |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKRISKSDYV | KNQDVIVFEE | AFDTSARKIL | LDNLREEYPY | QTDVVGRTKK | NWDASLGNFR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SYSLVNGGVV | ILSKWPIEEK | IQYIFNDSGC | GADWFANKGF | VYVKINKEGK | KFHVIGTHAQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SQDQNCSNLG | IPNRANQFDD | IRNFIYSKNI | PKDETVLIVG | DLNVIKESNE | YYDMISRLNV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NEPRYVGVPF | TWDAKTNEIA | AYYYENEEPV | YLDYIFVSKS | HAQPPVWQNL | AYDPVSKQTW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVSGYTSDEF | SDHYPIYGFV | YADPSTPTKS | GHKKKYDQVS | FQSAANGKYI | QADPNRKNGW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LKADAVIETD | FTKFNLLQEG | NLNPSCIKNG | LVRIESSRFL | NYFWNWWLGG | GSGNYGYYSK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FNDASNQLEI | INLSDECLEN | GSKIVFKDYD | TYSRNHYYLT | VWDKGNWNEH | LYLWKDSISQ |
| 610 | 620 | ||||
| REIFYLKLNS | TPVRNWSADL | IYR |