P58781

PR
Gene name
ada2a
Protein name
Adenosine deaminase 2-A
Names
Cat eye syndrome critical region protein 1 homolog A
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:373884
EC number
3.5.4.4: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58781

Entry ID Method Resolution Chain Position Source
AF-P58781-F1 Predicted AlphaFoldDB

No variants for P58781

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P58781

No associated diseases with P58781

2 regional properties for P58781

Type Name Position InterPro Accession
domain Adenosine deaminase domain 193 - 490 IPR001365
domain Adenosine/AMP deaminase N-terminal 29 - 95 IPR013659

Functions

Description
EC Number 3.5.4.4 In cyclic amidines
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

4 GO annotations of molecular function

Name Definition
adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3.
adenosine receptor binding Binding to an adenosine receptor.
proteoglycan binding Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
adenosine catabolic process The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
inosine biosynthetic process The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IG39 adal-1 Adenosine deaminase-like protein Caenorhabditis elegans PR
10 20 30 40 50 60
MHVLFLGDLM WIYLLLLCCA SCNGRPDPRK RDALIGLEAS RRTGGDITLN EREKLLDGKL
70 80 90 100 110 120
QKLKQHDMEA GQFPPSMHFF KAKRLIDQSP VFNLIQKMPK GAALHVHDFA MVSVDWLVKN
130 140 150 160 170 180
VTYRENCYVC FTDKQTVQFI FSSGPPASSS YCSSWTLLRS LREKIKNTTE LDNSFIRNLT
190 200 210 220 230 240
LFTEDPDRAY PNQDTVWERF EQVFLVAYGL VTYAPVFKDY LYEGLRQFYE DNIMYVEIRA
250 260 270 280 290 300
LLPQTYELDG RLNDKDWSMA ACQEVVNQFK KHHPDFIGAR VIFTVHRKIN ATEAVKTVEE
310 320 330 340 350 360
AMILRRNFPD VMAGFDFVGQ EDLGRPLWYF KDALSLPEDK GFNLPYFFHA GETDSQGTDV
370 380 390 400 410 420
DQNLMDALLF NTTRIGHGFA LARHPVVKEM ARKMDVPIEV CPISNQVLKL VSDLRDHPAA
430 440 450 460 470 480
VLMAEGHPLV ISSDDPAVFG ATALSHDFYE AFMGFGGMSF NLGTLKELAL NSLRYSTLPS
490 500
QRKEEAIDAL LVKWDKFVWE SLL