P58659
Gene name |
Eva1c (Fam176c) |
Protein name |
Protein eva-1 homolog C |
Names |
Protein FAM176C |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70967 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P58659
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P58659-F1 | Predicted | AlphaFoldDB |
24 variants for P58659
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs234563378 | 27 | P>S | No | EVA | |
| rs3389419091 | 43 | S>P | No | EVA | |
| rs3389394573 | 129 | R>Q | No | EVA | |
| rs3389419158 | 148 | S>N | No | EVA | |
| rs3389415324 | 172 | Q>* | No | EVA | |
| rs258109621 | 205 | A>V | No | EVA | |
| rs3389386060 | 267 | A>T | No | EVA | |
| rs3389341105 | 271 | A>V | No | EVA | |
| rs246177948 | 285 | H>N | No | EVA | |
| rs4218343 | 293 | G>R | No | EVA | |
| rs33588827 | 310 | A>T | No | EVA | |
| rs213698644 | 312 | A>T | No | EVA | |
| rs4218362 | 347 | T>R | No | EVA | |
| rs260158393 | 356 | G>R | No | EVA | |
| rs226984118 | 359 | H>Y | No | EVA | |
| rs3406945200 | 379 | D>N | No | EVA | |
| rs3389442272 | 383 | S>P | No | EVA | |
| rs33583874 | 384 | Q>E | No | EVA | |
| rs3389424524 | 384 | Q>H | No | EVA | |
| rs3406370252 | 389 | L>F | No | EVA | |
| rs3407265679 | 389 | L>S | No | EVA | |
| rs3389418831 | 410 | E>V | No | EVA | |
| rs3389419163 | 435 | N>T | No | EVA | |
| rs215104745 | 437 | G>S | No | EVA |
No associated diseases with P58659
3 regional properties for P58659
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | D-galactoside/L-rhamnose binding SUEL lectin domain | 67 - 159 | IPR000922-1 |
| domain | D-galactoside/L-rhamnose binding SUEL lectin domain | 168 - 260 | IPR000922-2 |
| domain | EVA1 domain | 300 - 440 | IPR039500 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| heparin binding | Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLPGHPRPP | PAPQSAQNQG | LRRQVEPPGQ | LLRLFYCTVL | VCSKETSALT | DFSGYLTKLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QNHTAYACDG | DYLNLQCPRH | STISVQSAFY | GQDYQMCSSQ | EPISQREDNL | TCVASTTLQK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLDECQNQRA | CHLLVNSRVF | GPDLCPGSSK | YLLVSFKCQP | NELKNKTVCE | NQELKLHCHE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SKFLNIYSAA | YGRRTQQRDI | CSSGAELLPP | FDCLSYTALQ | VLSRRCYGKQ | RCKVLVDNYH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGSPCLPGVK | KYLTVAYACV | PKNILTAVDP | AVANLNPSLK | KDDEHGITFN | PSGSRVVRKD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GVIVSNSLAA | FAYIRAHPER | AALLFMSSVC | IGLLLTLCAL | VIRVSCTKDF | RELRQGREHL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VLGSDKAEED | SEEDLEEEDS | SDSQFPEELS | RFCRTSYPAY | SSIEAAELAE | RIERREQVIQ |
| 430 | |||||
| EIWMNSGLDS | SLPRNVGHFY |