P58644

PR
Gene name
pyrF
Protein name
Orotidine 5'-phosphate decarboxylase
Names
OMP decarboxylase, OMPDCase, OMPdecase
Species
Yersinia pestis
KEGG Pathway
ypm:YP_2026
EC number
4.1.1.23: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58644

Entry ID Method Resolution Chain Position Source
AF-P58644-F1 Predicted AlphaFoldDB

No variants for P58644

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P58644

No associated diseases with P58644

2 regional properties for P58644

Type Name Position InterPro Accession
domain Orotidine 5'-phosphate decarboxylase domain 15 - 237 IPR001754
active_site Orotidine 5'-phosphate decarboxylase, active site 68 - 81 IPR018089

Functions

Description
EC Number 4.1.1.23 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.

2 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSATKTNNS GSISSPIVVA LDYANKDAAL AFADQVSPQD CRLKVGKEMF TLYGPELIRD
70 80 90 100 110 120
LHQRGFDVFL DLKFHDIPNT TARAVAAAAE LGVWMVNVHA SGGARMMSAA KEALLPYGAQ
130 140 150 160 170 180
APLLIAVTVL TSMDGEDLRD IGITISPAEQ AERLAKLTWD CGLDGVVCSA HEAVRLKQVC
190 200 210 220 230 240
GEDFSLVTPG IRPQGSEAGD QRRIMTPEQA VAVGVDYMVI GRPITQSPDP EKTLREILAS
LTKVA