P58559

PR
Gene name
gap3 (alr1095)
Protein name
Glyceraldehyde-3-phosphate dehydrogenase 3
Names
GAPDH 3, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
Species
Nostoc sp (strain PCC 7120 / SAG 2582 / UTEX 2576)
KEGG Pathway
ana:alr1095
EC number
1.2.1.12: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

159-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58559

Entry ID Method Resolution Chain Position Source
AF-P58559-F1 Predicted AlphaFoldDB

No variants for P58559

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P58559

No associated diseases with P58559

3 regional properties for P58559

Type Name Position InterPro Accession
domain Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain 3 - 153 IPR020828
domain Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain 158 - 315 IPR020829
active_site Glyceraldehyde 3-phosphate dehydrogenase, active site 151 - 158 IPR020830

Functions

Description
EC Number 1.2.1.12 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

2 GO annotations of biological process

Name Definition
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVRVGINGF GRMGRLALRA AWDWPELEFV HINEIKGGAV AAAHLLKFDS VHGRWTPEVE
70 80 90 100 110 120
AEGERVLIDG TPLSFSEYGK PDDVPWEDFG VDLVLECSGK FRTPATLDPY FKRGVQKVIV
130 140 150 160 170 180
AAPVKEEALN IVMGVNDYLY EPEKHHLLTA ASCTTNCLAP VVKVIHEGLG IKHGIITTIH
190 200 210 220 230 240
DNTNTQTLVD APHKDLRRAR ATSLSLIPTT TGSATAIALI YPELKGKLNG IAVRVPLLNA
250 260 270 280 290 300
SLTDCVFEVT RPTTVEEINA LLKAASEQAP LQGILGYEER PLVSIDYKDD PRSSIIDALS
310 320 330
TMVVDETQVK ILAWYDNEWG YVNRMVELAR KVALSLK