P58467
Gene name |
Setd4 |
Protein name |
SET domain-containing protein 4 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:224440 |
EC number |
2.1.1.364: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P58467
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P58467-F1 | Predicted | AlphaFoldDB |
20 variants for P58467
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389425543 | 13 | K>E | No | EVA | |
| rs3389428448 | 16 | R>W | No | EVA | |
| rs251482913 | 121 | C>R | No | EVA | |
| rs48948832 | 122 | R>L | No | EVA | |
| rs48948832 | 122 | R>Q | No | EVA | |
| rs1131727115 | 142 | L>W | No | EVA | |
| rs50362383 | 170 | T>A | No | EVA | |
| rs50362383 | 170 | T>S | No | EVA | |
| rs228630459 | 211 | R>K | No | EVA | |
| rs3389341189 | 271 | Y>F | No | EVA | |
| rs3389417085 | 271 | Y>H | No | EVA | |
| rs212877669 | 295 | V>I | No | EVA | |
| rs216204625 | 300 | D>E | No | EVA | |
| rs3389419729 | 311 | K>R | No | EVA | |
| rs258723082 | 313 | L>V | No | EVA | |
| rs230353208 | 317 | I>R | No | EVA | |
| rs3389341178 | 361 | L>P | No | EVA | |
| rs3389387387 | 369 | T>I | No | EVA | |
| rs240372969 | 385 | V>I | No | EVA | |
| rs261376787 | 433 | G>S | No | EVA |
No associated diseases with P58467
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.364 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone methyltransferase activity (H3-K4 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. |
| histone methyltransferase activity (H4-K20 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. |
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| histone H3-K4 dimethylation | The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone. |
| histone H3-K4 monomethylation | The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone. |
| histone H4-K20 trimethylation | The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| peptidyl-lysine monomethylation | The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. |
| peptidyl-lysine trimethylation | The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. |
| positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
| positive regulation of interleukin-6 production | Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. |
| positive regulation of tumor necrosis factor production | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. |
| regulation of cell proliferation in bone marrow | A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRRRGRTER | ARKRRRRSSG | SRAVNESYRS | EFIELRKWLK | ERKFEDTDLV | PASFPGTGRG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LMSKASLQEG | QVMISLPESC | LLTTDTVIRS | SLGPYIKKWK | PPVSPLLALC | TFLVSEKHAG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CRSLWKSYLD | ILPKSYTCPV | CLEPEVVDLL | PSPLKAKAEE | QRARVQDLFT | SARGFFSTLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLFAEPVDSV | FSYRAFLWAW | CTVNTRAVYL | RSRRQECLSA | EPDTCALAPF | LDLLNHSPHV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QVKAAFNEKT | RCYEIRTASR | CRKHQEVFIC | YGPHDNQRLL | LEYGFVSVRN | PHACVPVSAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MLVKFLPAAD | KQLHRKITIL | KDHGFTGNLT | FGWDGPSWRL | LTALKLLCLE | AERFTSWKKV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLGEVISDTN | EKTSLGVAQK | ICSDVIEETH | AVLRKVSDMK | EGTVSLRSQL | SLVEALRMEE |
| 430 | |||||
| LRILQASAEI | LSGLLAPFS |