P58404
PR
Gene name |
Strn4 (Zin) |
Protein name |
Striatin-4 |
Names |
Zinedin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:97387 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P58404
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P58404-F1 | Predicted | AlphaFoldDB |
37 variants for P58404
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs214470600 | 38 | A>V | No | EVA | |
| rs3388874625 | 132 | Y>F | No | EVA | |
| rs3388855853 | 150 | L>M | No | EVA | |
| rs3397661183 | 170 | V>E | No | EVA | |
| rs252478871 | 219 | A>P | No | EVA | |
| rs3388882342 | 249 | A>V | No | EVA | |
| rs3388883386 | 252 | D>N | No | EVA | |
| rs3388874062 | 258 | G>D | No | EVA | |
| rs238258302 | 279 | D>E | No | EVA | |
| rs229365381 | 290 | Q>P | No | EVA | |
| rs3388879788 | 312 | S>L | No | EVA | |
| rs3388883314 | 349 | R>S | No | EVA | |
| rs3388855843 | 372 | V>I | No | EVA | |
| rs3388855907 | 373 | P>L | No | EVA | |
| rs3388862323 | 380 | P>S | No | EVA | |
| rs3388881381 | 392 | D>V | No | EVA | |
| rs3388879608 | 393 | V>A | No | EVA | |
| rs3397632040 | 394 | F>* | No | EVA | |
| rs3388870233 | 405 | S>N | No | EVA | |
| rs3388885979 | 408 | D>N | No | EVA | |
| rs3388879779 | 447 | G>S | No | EVA | |
| rs3388881404 | 456 | S>N | No | EVA | |
| rs3388874641 | 459 | A>G | No | EVA | |
| rs1134550721 | 486 | L>M | No | EVA | |
| rs3388855833 | 506 | M>L | No | EVA | |
| rs3388843344 | 508 | S>N | No | EVA | |
| rs3388885401 | 532 | M>L | No | EVA | |
| rs3397641393 | 543 | L>Q | No | EVA | |
| rs3388885410 | 581 | S>T | No | EVA | |
| rs31961396 | 594 | D>A | No | EVA | |
| rs3388866080 | 641 | S>R | No | EVA | |
| rs3388882812 | 651 | V>M | No | EVA | |
| rs3388884960 | 658 | L>H | No | EVA | |
| rs3388881364 | 661 | T>N | No | EVA | |
| rs3397697091 | 713 | W>R | No | EVA | |
| rs3388866145 | 721 | V>E | No | EVA | |
| rs3388879804 | 726 | A>G | No | EVA |
No associated diseases with P58404
11 regional properties for P58404
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 434 - 482 | IPR001680-1 |
| repeat | WD40 repeat | 487 - 527 | IPR001680-2 |
| repeat | WD40 repeat | 540 - 579 | IPR001680-3 |
| repeat | WD40 repeat | 584 - 626 | IPR001680-4 |
| repeat | WD40 repeat | 629 - 672 | IPR001680-5 |
| repeat | WD40 repeat | 675 - 760 | IPR001680-6 |
| domain | Striatin, N-terminal | 64 - 192 | IPR013258 |
| conserved_site | WD40 repeat, conserved site | 460 - 474 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 460 - 474 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 566 - 580 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 701 - 715 | IPR020472-3 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| FAR/SIN/STRIPAK complex | A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| armadillo repeat domain binding | Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein phosphatase 2A binding | Binding to protein phosphatase 2A. |
| protein-containing complex binding | Binding to a macromolecular complex. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMEERAAAAV | ASAASSCRPL | GSGTAPNPTA | AAPASSPAPG | PGPVGKGGGG | GGSPGPTAGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EPLSLPGILH | FIQHEWARFE | AEKARWEAER | AELQAQVAFL | QGERKGQENL | KTDLVRRIKM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEYALKQERA | KYHKLKFGTD | LNQGEKKTDL | SEQVSNGPVE | SVTLENSPLV | WKEGRQLLRQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLEEVGYTDT | ILDMRSKRVR | SLLGRSLELN | GAGEPVEGAP | RASPGPGGLS | GGESLLVKQI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEQIKRNAAG | KDGKERLGGS | VLEQIPFLQN | CEDEDSDEDD | ELDSVQHKKQ | RVRLPSKALV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PEMEDEDEED | DSEDAINEFD | FLGSGEDGEG | SPDPRRCTSE | GNPHELESRR | VKLQGILADL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RDVDGLPPKV | TVPPPGTPQP | RPHEGSFGFS | SDVFIMDTIG | GGEVSLGDLA | DLTVTNDNDL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SCDLSDSKDA | FKKTWNPKFT | LRSHYDGIRS | LAFHHSQSAL | LTASEDGTLK | LWNLQKAVTA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKNAALDVEP | IHAFRAHRGP | VLAVTMGSNS | EYCYSGGADA | RIHSWKIPDL | NMDPYDGYDP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SVLSHVLEGH | GDAVWGLAFS | PTSQRLASCS | ADGTVRIWDP | SSSGPSCLCT | FPMDGEHGIP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TSVAFTSTEP | AHVVASFRSG | DTVLYDLEAG | SALLTLESRG | SSGPAQINQV | VSHPSQPLTI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TAHDDRGIRF | LDNRTGKSVH | SMVAHLDAVT | CLAVDPNGVF | LMSGSHDCSL | RLWSLDNKTC |
| 730 | 740 | 750 | |||
| VQEITAHRKK | HEEAIHAVAC | HPSKALIASA | GADALAKVFV |