P58028
Gene name |
MAOB |
Protein name |
Amine oxidase [flavin-containing] B |
Names |
Monoamine oxidase type B, MAO-B |
Species |
Cavia porcellus (Guinea pig) |
KEGG Pathway |
cpoc:100135573 |
EC number |
1.4.3.4: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P58028
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P58028-F1 | Predicted | AlphaFoldDB |
No variants for P58028
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P58028 | |||||
No associated diseases with P58028
1 regional properties for P58028
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amine oxidase | 14 - 451 | IPR002937 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.3.4 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aliphatic amine oxidase activity | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. |
| monoamine oxidase activity | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNSKCDVVVV | GGGISGLAAA | KLLHDSGLNV | VVLEARDCVG | GRTYTLRNQN | VKYVDLGGAY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGPTQNRILR | LAKELGLETY | RVNDVERQIH | HVKGKSYPFR | GPFPPAWNPI | SYLDHNNLWR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TMDDMGKEIP | SDAPWKAPLA | EEWDHMTMKE | LLNKICWTNC | PRQFGTLFVN | LCFTAETHEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SALWFLWYVK | QCGGTTRIIS | TTNGGQERKF | VGGSGQISER | IMNLLGDRVK | LQRPVVYIDQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGESVLVETL | NHEIYEAKYV | ISAIPPALGM | KIHFKPPLPM | MKNQLVSRVP | LGSVIKCIVY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKDPFWRKKD | FCGTMVIEGE | EAPVLYTMDD | TKPDGSYAAI | IGFIAAHKAR | KLARLTKEER |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKKLCELYAK | VLGSKEALKP | VHYEEKNWCE | EQYSGGCYTA | YFPPGIMTQY | GRFLRQPVGR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IFFAGTETAT | HWSGYMEGAV | EAGERAAREV | LNAIGKIPED | EIWQPEPESV | DVPAQPITTT |
| 490 | 500 | 510 | |||
| FLERHLPSVP | GLLRLIRLTT | VVSAVALGFL | AQKRGLLLRI |