P58003

PR
Gene name
sesn1
Protein name
Sestrin-1
Names
XPA26, p53-regulated protein PA26
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:379559
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

246-323 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58003

Entry ID Method Resolution Chain Position Source
AF-P58003-F1 Predicted AlphaFoldDB

No variants for P58003

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P58003

No associated diseases with P58003

No regional properties for P58003

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P58003

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
leucine binding Binding to 2-amino-4-methylpentanoic acid.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

2 GO annotations of biological process

Name Definition
negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
regulation of response to reactive oxygen species Any process that modulates the frequency, rate or extent of response to reactive oxygen species.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLSPRAALS SPEIICSRCS QSCNNKELGI RIPRPLGQGP SRFVPEEEIL QLASEDANMH
70 80 90 100 110 120
SVFADAFTDL GRLDNITLVM VFHPQYLESF LKTQHYLLQM DGPLSPCYQH YIGIMAASRH
130 140 150 160 170 180
QCSYLVNLHV NDFIHHGGDQ KWLNGLENAP QKLRNLGELN KMLAHRPWLI TKEHIKQLLK
190 200 210 220 230 240
AGEHSWSLAE LIHAIVLLAH YHSLASFTFG CGINPEIHSN GGHTFRPPSV SNYCICDITN
250 260 270 280 290 300
GNHGTEGHLP VGIVMPTDST CEVEALMVKM KQLQEGRDEE EASQEEMATR FEREKTESMV
310 320 330 340 350 360
FSTEDEDPPP DIDVSRHFED TSYGYKDFSR RGMHVPTFRV QDYSWEDHGY SLVNRLYPDV
370 380 390 400 410 420
GQLLDEKFHI AYNLTYNTMA MHKDVDTSTL RRAVWNYVHC MFGIRYDDYD YGEINQLLDR
430 440 450 460 470 480
SFKVYIKNVV CSPEKTSKRM YDGFWRQFKH SEKVHVNLLL MEARMQGELL YALRAITRYM
T