P57822

PR
Gene name
lysS (lysU, PM0189)
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Pasteurella multocida (strain Pm70)
KEGG Pathway
pmu:PM0189
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P57822

Entry ID Method Resolution Chain Position Source
AF-P57822-F1 Predicted AlphaFoldDB

No variants for P57822

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P57822

No associated diseases with P57822

4 regional properties for P57822

Type Name Position InterPro Accession
binding_site Catalase haem-binding site 333 - 341 IPR002226
domain Catalase immune-responsive domain 415 - 475 IPR010582
domain Catalase core domain 7 - 391 IPR011614
active_site Catalase active site 43 - 59 IPR024708

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEQTQELDL NGEMLVRREK LAALRAKGNP FPNTFRRDAL AQDLHANYDA LEGEALKAQE
70 80 90 100 110 120
VEVKVAGRIM TRRAMGKATF ITLQDMSGRI QLYVARDNLP EGIYADDVGQ WDLGDIIGVK
130 140 150 160 170 180
GTLFKTKTNE LTVRCTEVQL LTKALRPLPD KFHGLSDQET RYRQRYLDLI ANEDSRRTFI
190 200 210 220 230 240
IRSKVIAGIR EYFLSKGFME VETPMLQIIP GGASARPFVT HHNALDVDMY LRIAPELYLK
250 260 270 280 290 300
RLVVGGFERV FELNRNFRNE GVSVRHNPEF TMLEYYQAYA DYHDLMDNTE ELLRKLAMDI
310 320 330 340 350 360
LGTTIVPYGE LEFDFGKPFE RITMHDAILK YGAEKGIVKE DLYDFDRAVA VAKKLGIEVQ
370 380 390 400 410 420
KSWGLGSLVN VIFEEVAEHH LIQPTFLMAH PAEISPLARR NDENPEVTDR FELFIGGREI
430 440 450 460 470 480
GNGFSELNDA EDQNERFDAQ VAAKEAGDDE AMFKDEDFVT ALEHGLPPTA GEGLGIDRLA
490 500
MLFANAASIR DVILFPAMKQ K