P57677

PR
Gene name
lysS (Ta1163)
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
KEGG Pathway
tac:Ta1163
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

297-366 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P57677

Entry ID Method Resolution Chain Position Source
AF-P57677-F1 Predicted AlphaFoldDB

No variants for P57677

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P57677

No associated diseases with P57677

2 regional properties for P57677

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 26 - 35 IPR001412
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 422 - 504 IPR045462

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MISLFWADAL VKDLSGPQRV STGISPSGPI HVGNMREILT GDILFKAITK RGLESDFIYL
70 80 90 100 110 120
CDDMDPLRKV YPFLSKDYER YVGQPLKNIP APQGAGKYSD YYLEPFVRVM KEANIPARVI
130 140 150 160 170 180
KTSDLYESGM LAQACDIAIN NREKIKDILE TVSGRKIEGD FYPYEPLCEK CGRISTTHVI
190 200 210 220 230 240
SYSYPYAEYA CKCGHHGFAD IRKAEGKMPW RVEWPAKWFA LKVTVEPFGK DHGAPGGSYD
250 260 270 280 290 300
TGRRIAREVF GIEPPVPLMY ERIILKGKGA MHSSTGLAIA ASEIMEVIPP DLLRYMIARV
310 320 330 340 350 360
NPGRHIDFDP GMGILALSDE LEKLQDAYFE NRASLDEDQA AMVEYSLVNK DRKPYPVDFR
370 380 390 400 410 420
HLVTLVQIYR TEDEILRAVK KGQPSDFIEA DFRKEIEYAR RWLERYAPES VKFRILPVDQ
430 440 450 460 470 480
KIELSDSDLA ILSDFLNGIE DMPWNSESIH DRIYEISQKF KTNPESVFTL FYRVFIGKDR
490 500
GPRLGYFLFN LGKDFVRERI RNVIRDH