P57611
Gene name |
dnaB (BU546) |
Protein name |
Replicative DNA helicase |
Names |
|
Species |
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) |
KEGG Pathway |
buc:BU546 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P57611
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P57611-F1 | Predicted | AlphaFoldDB |
No variants for P57611
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P57611 | |||||
No associated diseases with P57611
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| primosome complex | Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication, synthesis of RNA primer | The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKDKLYLNQ | INRLKIPPHS | LEAEQSVLGG | LMLDNEQWDS | VSEHVVADDF | FSKPHRLIFQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EMQKLLDLGY | PIDLITLSES | LEQKGKLESV | GRFSYLAELS | KNTPSTANIT | AYADIVRERA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IVREMILVAN | KIANAGYDTQ | GRKSEELLDY | AESSVFKIAE | KRFKKDSGPK | NVEQILDETV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASIEKLFLSP | HDGVTGINTG | YQDLNKKTSG | LQRSELIIIA | ARPSMGKTTF | AMNLCENAAM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LYDKPVLIFS | LEMPGEQIMM | RMLASLSRVN | QARIRTGQLN | NEDWARISGT | INILLKKKNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YIDDSSALTP | SEVRSRARRI | YRENNGLTLI | MVDYLQLMRV | PSLSENRTLE | IAEISRTLKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAKELQVPVI | ALSQLNRSLE | QRSDKRPVNS | DLRESGSLEQ | DADLIMFIYR | DEIYNENSDL |
| 430 | 440 | 450 | |||
| KGIAEIIIGK | QRNGPIGTVR | LTFNGHWSRF | DNYSGQKYD |