P57551

PR
Gene name
mdlA (BU479)
Protein name
Multidrug resistance-like ATP-binding protein MdlA
Names
Species
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
KEGG Pathway
buc:BU479
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

288-359 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P57551

Entry ID Method Resolution Chain Position Source
AF-P57551-F1 Predicted AlphaFoldDB

No variants for P57551

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P57551

No associated diseases with P57551

4 regional properties for P57551

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 334 - 571 IPR003439
domain AAA+ ATPase domain 361 - 548 IPR003593
domain ABC transporter type 1, transmembrane domain 19 - 303 IPR011527
conserved_site ABC transporter-like, conserved site 473 - 487 IPR017871

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLFNQLRWF FVREWKRYLG AILLLIIIAT LQLLPPKIVG VLIDLIIKKN MHGVQILPWI
70 80 90 100 110 120
LIIFLVAVIV YILRYLWRIL LFGASYQLAT ELRVKFYTYL SQQSQIFFLK NRTGDLIARA
130 140 150 160 170 180
TNDVDRVVFA AGEGVLTLVD SLVMGFSVLI VMSTQISFLL TIISLIPMPI MAILIKKYGK
190 200 210 220 230 240
ELHETFRHAQ ISFSLLNNQT QEILTSIRMI RAFGLEKNQS NKFNIITRNT GKKNMEVAKI
250 260 270 280 290 300
DARFDPVIYL SVAFSNLLAI IGGGWLVWNN QISIGQLTSF IMYLGLMIWP MLALAWMFNI
310 320 330 340 350 360
VERGSAAWDR IHSIINKKLY IEDGKNNIPP YPGILNINIK KFYYPNNQKP SLKDIRILIK
370 380 390 400 410 420
PGNTLGICGP TGSGKSTLLM LIQRQFNFKK EEIHYHSLSL LEIKIDDWRR RIAVVNQTSF
430 440 450 460 470 480
LFSDTISNNI SLGKPNASQK EIEEVAKLAD VHKDIIDLPE RYETQVGERG VMLSGGQKQR
490 500 510 520 530 540
VCIARALLLN AEILILDDAL SAVDAQTENN ILKNINEWKK KKHSLIITTH RLSALINSDE
550 560 570 580
IIVIKSGSII QRGNHLKLIQ EKNWYKSMYY YQQSEIELED NEKTGEKNL