P57453

PR
Gene name
deaD
Protein name
ATP-dependent RNA helicase DeaD
Names
Cold-shock DEAD box protein A
Species
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
KEGG Pathway
buc:BU372
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

534-601 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P57453

Entry ID Method Resolution Chain Position Source
AF-P57453-F1 Predicted AlphaFoldDB

No variants for P57453

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P57453

No associated diseases with P57453

7 regional properties for P57453

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 154 - 162 IPR000629
domain Helicase, C-terminal 231 - 378 IPR001650
domain DEAD box helicase DbpA/CsdA, RNA-binding domain 478 - 547 IPR005580
domain DEAD/DEAH box helicase domain 31 - 195 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 25 - 223 IPR014001
domain RNA helicase, DEAD-box type, Q motif 6 - 34 IPR014014
domain CsdA, RNA recognition motif 477 - 549 IPR034415

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
cellular response to cold Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTHIESTFSF LGLNPFIIQS LNEMGYVKPS PIQASCIPLL LEGRDVLGMA QTGSGKTAAF
70 80 90 100 110 120
SLPLLHNLNI NLKAPQILVL APTRELAVQV AEAFSDFSKY MIGIHVLPLY GGQRYELQLR
130 140 150 160 170 180
ALRQGPQIVV GTPGRLLDHL KRGTLNLSNL HGLVLDEADE MLRMGFIEDV ETIMAQIPKE
190 200 210 220 230 240
HQTALFSATM PEAIRRISKR FMRNPKEIKI QSNITTRPDI KQSYWMVYGR KTDALIRFLE
250 260 270 280 290 300
AEDFSATIIF VRTKNATLEV SEALERNGYN SAALNGDMNQ ALREQTLERL KNGRLDILIA
310 320 330 340 350 360
TDVAARGLDV DRISFVINYD IPMDSESYVH RIGRTGRAGR AGRALLFVEN RERRLLRNIE
370 380 390 400 410 420
RTMKQSIPEV QLPKVELLCQ RRLEQFAKKV QQQLESRDLD EYSALLDKLY STDDLDIKTL
430 440 450 460 470 480
AAALLKMAQG ERPLIIKPDV IKRQSRDLLF QDDRRREDNR NSRTRRDRRD INKDAELYRI
490 500 510 520 530 540
EVGRNDGVEV RHIVGAIANE GNINSRNIGN IKLFSSYSTI ELPKGMSKDL LQTFNRTRIL
550 560 570 580 590 600
NKPINMKLLR DSRHYENKTT HRSIFNKDKN SNRRVSDGSF NKSNSPKKTE FKSSFFRRRN
V