P57100

PR
Gene name
HAND1 (EHAND)
Protein name
Heart- and neural crest derivatives-expressed protein 1
Names
Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1, eHAND
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P57100

Entry ID Method Resolution Chain Position Source
AF-P57100-F1 Predicted AlphaFoldDB

No variants for P57100

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P57100

No associated diseases with P57100

1 regional properties for P57100

Type Name Position InterPro Accession
domain Myc-type, basic helix-loop-helix (bHLH) domain 94 - 152 IPR011598

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleoplasm
  • Nucleus, nucleolus
  • Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity
  • Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
trophoblast giant cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLVGSYAHH HHHHHPHPAH PMLHEPFLFG PASRCHQERP YFQSWLLSPA DAAPDFPTGG
70 80 90 100 110 120
PPPTAAAAAA TYGPDTRPGQ SPGRLEALGG RLGRRKGSGP KKERRRTESI NSAFAELREC
130 140 150 160 170 180
IPNVPADTKL SKIKTLRLAT SYIAYLMDVL AKDAQAGDPE AFKAELKKVD GGRESKRKRE
190 200 210
LQQHEGFPPA LGPGEKRIKG RTGWPQQVWA LELNQ