P56881

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
KEGG Pathway
ttj:TTHA1875
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P56881

Entry ID Method Resolution Chain Position Source
AF-P56881-F1 Predicted AlphaFoldDB

No variants for P56881

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P56881

No associated diseases with P56881

7 regional properties for P56881

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 336 - 546 IPR002314
domain TGS 1 - 60 IPR004095
domain Anticodon-binding 559 - 644 IPR004154
domain Aminoacyl-tRNA synthetase, class II 283 - 552 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 174 - 228 IPR012947
domain Threonine-tRNA ligase catalytic core domain 252 - 555 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 566 - 644 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVYLPDGKP LELPEGATAK DVARALGEGW ERRAVGAIVD GELYDLLKPL PQGAKVRLLT
70 80 90 100 110 120
EKDPEFQTLF RHTLAHVLAQ AVKEFFREKG YDPESVRLGV GPVIEKGFYY DIEAPEPLSD
130 140 150 160 170 180
EDLPAIEAKM REILKRDLPL RRFVLSREEA LARYRGKDPY KTELVLEIPE GEEISFYQQG
190 200 210 220 230 240
DEAYGFTDLC RGPHVPSTGR IPPHFKLTHV AGAYWRGDEN RPMLQRVYGV AFRTAEELKE
250 260 270 280 290 300
YLWQLEEAKK RDHRRLGREL ELFLIDPLVG KGLVLWLPKG NVVREELMAF MREEQVRRGY
310 320 330 340 350 360
QLVTTPHIGS LELYKTSGHY PYYAESQFPP ISFKERGEEE EYLLKPMNCP HHIRIYAYRK
370 380 390 400 410 420
RSYRELPLRL AEFGTVYRYE KAGELLGLTR VRGFTQDDAH IFCTPEEVKG EFLGVLDLVL
430 440 450 460 470 480
KVFATLGLKD YRARIGVRDP KSDKYVGDEA KWALAERQIE EAAAEAGLRY TVEEGDAAFY
490 500 510 520 530 540
GPKLDFVVKD ALGREWQLGT IQVDYNLPER FGLTYVGKDG EEHRPVMLHR APFGSLERFI
550 560 570 580 590 600
GILIEHFAGD FPLWLAPVQA VVVPVSEKQE DYAREVAGRL KEAGLRAEAD TRPERMQARI
610 620 630 640 650
RDAEVQKVPY ILVVGEREKA EGAVSVRRRK KGNLGTMPLA AFLEGALREY RERRLEPVF