P56859

PR
Gene name
sA (AN4770)
Protein name
Phosphoadenosine phosphosulfate reductase
Names
3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAdoPS reductase
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN4770.2
EC number
1.8.4.8: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P56859

Entry ID Method Resolution Chain Position Source
AF-P56859-F1 Predicted AlphaFoldDB

No variants for P56859

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P56859

No associated diseases with P56859

2 regional properties for P56859

Type Name Position InterPro Accession
conserved_site DNA methylase, N-6 adenine-specific, conserved site 128 - 134 IPR002052
domain Type II restriction enzyme and methyltransferase RM.Eco57I-like 128 - 236 IPR011639

Functions

Description
EC Number 1.8.4.8 With a disulfide as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
phosphoadenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.

5 GO annotations of biological process

Name Definition
cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
hydrogen sulfide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.
sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPAKMHSNYP SDSETAELRD STESGYVSGG SSEEYLPEIV FTKPHLQFLN RQLQFLEPQD
70 80 90 100 110 120
VLRWCVTSLP HLYQTTAFGL TGLVIMDMLS KLSIPRPQMV NLIFLDTLHH FPETLKLVDN
130 140 150 160 170 180
VRKRYPLQHI HVYKPQGVET EEEFAKKHGE RLWEKDDQLY DWIAKVEPAQ RAYRELNVHA
190 200 210 220 230 240
VLTGRRRSQG GKRGDLDIIE VDEAGLIKIN PLANWTFDQV KQYVKENDIP YNELLDKGYK
250 260 270 280 290 300
SVGDYHSTSP VKENEDERSG RWKGQAKTEC GIHNPRSKYA QYLMDMERKR QEEALSQALQ
NKLTTA