P56689

PR
Gene name
pol (polA)
Protein name
DNA polymerase
Names
TO POL
Species
Thermococcus gorgonarius
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

206-275 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P56689

Entry ID Method Resolution Chain Position Source
1TGO X-ray 250 A A 1-773 PDB
2VWJ X-ray 278 A A 1-773 PDB
2VWK X-ray 260 A A 1-773 PDB
2XHB X-ray 272 A A 1-773 PDB
7B06 X-ray 235 A A 1-773 PDB
7B07 X-ray 310 A A 1-773 PDB
7B08 X-ray 239 A A 1-773 PDB
7B0F X-ray 280 A A 1-773 PDB
7B0G X-ray 300 A A 1-773 PDB
7B0H X-ray 315 A E/F 1-773 PDB
AF-P56689-F1 Predicted AlphaFoldDB

No variants for P56689

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P56689

No associated diseases with P56689

4 regional properties for P56689

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 24 - 129 IPR006133-1
domain DNA-directed DNA polymerase, family B, exonuclease domain 130 - 278 IPR006133-2
domain DNA-directed DNA polymerase, family B, multifunctional domain 352 - 746 IPR006134
conserved_site DNA-directed DNA polymerase, family B, conserved site 538 - 546 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILDTDYITE DGKPVIRIFK KENGEFKIDY DRNFEPYIYA LLKDDSAIED VKKITAERHG
70 80 90 100 110 120
TTVRVVRAEK VKKKFLGRPI EVWKLYFTHP QDVPAIRDKI KEHPAVVDIY EYDIPFAKRY
130 140 150 160 170 180
LIDKGLIPME GDEELKMLAF DIETLYHEGE EFAEGPILMI SYADEEGARV ITWKNIDLPY
190 200 210 220 230 240
VDVVSTEKEM IKRFLKVVKE KDPDVLITYN GDNFDFAYLK KRSEKLGVKF ILGREGSEPK
250 260 270 280 290 300
IQRMGDRFAV EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AIFGQPKEKV YAEEIAQAWE
310 320 330 340 350 360
TGEGLERVAR YSMEDAKVTY ELGKEFFPME AQLSRLVGQS LWDVSRSSTG NLVEWFLLRK
370 380 390 400 410 420
AYERNELAPN KPDERELARR RESYAGGYVK EPERGLWENI VYLDFRSLYP SIIITHNVSP
430 440 450 460 470 480
DTLNREGCEE YDVAPQVGHK FCKDFPGFIP SLLGDLLEER QKVKKKMKAT IDPIEKKLLD
490 500 510 520 530 540
YRQRAIKILA NSFYGYYGYA KARWYCKECA ESVTAWGRQY IETTIREIEE KFGFKVLYAD
550 560 570 580 590 600
TDGFFATIPG ADAETVKKKA KEFLDYINAK LPGLLELEYE GFYKRGFFVT KKKYAVIDEE
610 620 630 640 650 660
DKITTRGLEI VRRDWSEIAK ETQARVLEAI LKHGDVEEAV RIVKEVTEKL SKYEVPPEKL
670 680 690 700 710 720
VIYEQITRDL KDYKATGPHV AVAKRLAARG IKIRPGTVIS YIVLKGSGRI GDRAIPFDEF
730 740 750 760 770
DPAKHKYDAE YYIENQVLPA VERILRAFGY RKEDLRYQKT RQVGLGAWLK PKT