P56477

PR
Gene name
Irf5
Protein name
Interferon regulatory factor 5
Names
IRF-5
Species
Rattus norvegicus (Rat)
KEGG Pathway
mmu:27056
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

430-497 (C-terminal autoinhibitory region) SS

Target domain

246-430 (IFN association domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P56477

Entry ID Method Resolution Chain Position Source
AF-P56477-F1 Predicted AlphaFoldDB

3 variants for P56477

Variant ID(s) Position Change Description Diseaes Association Provenance
rs585125464 126 A>G No Ensembl
rs259714691 261 R>Q No Ensembl
rs258156314 495 G>S No Ensembl

No associated diseases with P56477

2 regional properties for P56477

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 169 - 424 IPR000536
domain Zinc finger, nuclear hormone receptor-type 25 - 100 IPR001628

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
identical protein binding Binding to an identical protein or proteins.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

11 GO annotations of biological process

Name Definition
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of type I interferon production Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
response to peptidoglycan Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58DJ0 IRF5 Interferon regulatory factor 5 Bos taurus (Bovine) SS
Q13568 IRF5 Interferon regulatory factor 5 Homo sapiens (Human) EV
Q61179 Irf9 Interferon regulatory factor 9 Mus musculus (Mouse) PR
Q64287 Irf4 Interferon regulatory factor 4 Mus musculus (Mouse) EV
P70671 Irf3 Interferon regulatory factor 3 Mus musculus (Mouse) SS
P70434 Irf7 Interferon regulatory factor 7 Mus musculus (Mouse) SS
P23611 Irf8 Interferon regulatory factor 8 Mus musculus (Mouse) PR
10 20 30 40 50 60
MRGPLGTEEE LPRLFAEEME NEEEMSEEED GGLEGFEDFF PAEPVSLPKK KPKKLKESKS
70 80 90 100 110 120
KGKRKKKEGS NDELSENEED LEEKSESEGS DYSPTKKKKK KLKEKKEKKA KRKKRDEDEE
130 140 150 160 170 180
DNEDGGLKEP KSSGQLMAEW GLDDVDYLFS EDDYHTLTNY KAFSQFLRPL IAKKNPKIPM
190 200 210 220 230 240
SKMMTVLGAK WREFSANNPF KGSSAAAAAA AVAAAVETVT IAPPLAISPQ QVPQPLPVRK
250 260 270 280 290 300
AKTKEGKGPG VRKKNKGAKD SKKKGRGKRV AGLKFRFGGI SKRKKGSSSE EDEPEDSDLD
310 320 330 340 350 360
NASIHSSSVR SECSAALGKK NKRRRKKKRI DDGDGYETDH QDYCEVCQQG GEIILCDTCP
370 380 390 400 410 420
RAYHLVCLDP ELEKAPEGKW SCPHCEKEGI QWEPKDDDEE EEEGGCEEEE DDHMEFCRVC
430 440 450 460 470 480
KDGGELLCCD ACPSSYHLHC LNPPLPEIPN GEWLCPRCTC PPLKGKVQRI LHWRWTEPPA
490 500 510 520 530 540
PFMVGLPGPE VEPGMPPPRP LEGIPEREFF VKWAGLSYWH CSWVKELQLE LYHTVMYRNY
550 560 570 580 590 600
QRKNDMDEPP PFDYGSGDED GKSEKRKNKD PLYAKMEERF YRYGIKPEWM MVHRILNHSF
610 620 630 640 650 660
DKKGDVHYLI KWKDLPYDQC TWEIDEIDIP YYDNLKQTYW GHRELMLGED ARLPKRLVKK
670 680 690 700 710 720
GKKLKDDKQE KPPDTPIVDP TVKFDKQPWY IDSTGGTLHP YQLEGLNWLR FSWAQGTDTI
730 740 750 760 770 780
LADEMGLGKT VQTIVFLYSL YKEGHSKGPY LVSAPLSTII NWEREFEMWA PDFYVVTYTG
790 800 810 820 830 840
DKESRSVIRE NEFSFEDNAI RGGKKVFRMK KEVQIKFHVL LTSYELITID QAILGSIEWA
850 860 870 880 890 900
CLVVDEAHRL KNNQSKFFRV LNSYKIDYKL LLTGTPLQNN LEELFHLLNF LTPERFNNLE
910 920 930 940 950 960
GFLEEFADIS KEDQIKKLHD LLGPHMLRRL KADVFKNMPA KTELIVRVEL SQMQKKYYKF
970 980 990 1000 1010 1020
ILTRNFEALN SKGGGNQVSL LNIMMDLKKC CNHPYLFPVA AVEAPMLPNG SYDGSSLVKS
1030 1040 1050 1060 1070 1080
SGKLMLLQKM LKKLRDEGHR VLIFSQMTKM LDLLEDFLEY EGYKYERIDG GITGGLRQEA
1090 1100 1110 1120 1130 1140
IDRFNAPGAQ QFCFLLSTRA GGLGINLATA DTVIIYDSDW NPHNDIQAFS RAHRIGQNKK
1150 1160 1170 1180 1190 1200
VMIYRFVTRA SVEERITQVA KRKMMLTHLV VRPGLGSKSG SMTKQELDDI LKFGTEELFK
1210 1220 1230 1240 1250 1260
DDVEGMMSQG QRPTTPIPDV QSTKGGSLAA GAKKKHGGTP PGDNKDVEDS SVIHYDDAAI
1270 1280 1290 1300 1310 1320
SKLLDRNQDA TDDTELQNMN EYLSSFKVAQ YVVREEDGVE EVEREVIKQE ENVDPDYWEK
1330 1340 1350 1360 1370 1380
LLRHHYEQQQ EDLARNLGKG KRIRKQVNYN DASQEDQEWQ DELSDNQSEY SIGSEDEDED
1390 1400 1410 1420 1430 1440
FEERPEGQSG RRQSRRQLKS DRDKPLPPLL ARVGGNIEVL GFNARQRKAF LNAIMRWGMP
1450 1460 1470 1480 1490 1500
PQDAFNSHWL VRDLRGKSEK EFRAYVSLFM RHLCEPGADG AETFADGVPR EGLSRQHVLT
1510 1520 1530 1540 1550 1560
RIGVMSLVRK KVQEFEHVNG KYSTPDLVPE GPEGKKPGEV ISSDPNTPVP ASPAQLPPAP
1570 1580 1590 1600 1610 1620
LGLPDKMEAQ LGYTDEKESG TQKPKKSLEI QALPTALDRV EAEDKHQSSD SKDRAREERM
1630 1640 1650 1660 1670 1680
EEVEKAQGSP EQPLKEETLP DKEPVPDKLE LSLSHSNDFR PDDPKAEEKE PTETQQNGDR
1690 1700 1710 1720 1730 1740
EEDEEGKKED KNGKFKFMFN IADGGFTELH TLWQNEERAA VSSGKIYEIW HRRHDYWLLA
1750 1760 1770 1780 1790 1800
GIVTHGYARW QDIQNDPRYM ILNEPFKSEV HKGNYLEMKN KFLARRFKLL EQALVIEEQL
1810 1820 1830 1840 1850 1860
RRAAYLNMTQ DPNHPAMALN ARLAEVECLA ESHQHLSKES LAGNKPANAV LHKVLNQLEE
1870 1880 1890 1900 1910 1920
LLSDMKADVT RLPSMLSRIP PVAARLQMSE RSILSRLTNR AGDPTIQQGA FGSSQMYNNS
1930 1940
FGPNFRGPGP GGIVNYNQMP LGPYVTGR