P56468

PR
Gene name
purB (HP_1112)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
KEGG Pathway
hpy:HP_1112
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

227-296 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P56468

Entry ID Method Resolution Chain Position Source
AF-P56468-F1 Predicted AlphaFoldDB

No variants for P56468

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P56468

No associated diseases with P56468

3 regional properties for P56468

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 349 - 439 IPR019468
conserved_site Fumarate lyase, conserved site 261 - 270 IPR020557
domain Fumarate lyase, N-terminal 7 - 284 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

2 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLERYANEEM KALWNEQTKF ETYLEVEKAV VRAWNKLGQI QDSDCEKICA KAAFNLERIK
70 80 90 100 110 120
EIEKTTKHDL IAFTTCVAES LGEESRFFHY GITSSDCIDT AMALLMTKSL KLIQKGVKNL
130 140 150 160 170 180
YETLKNRALE HKDTLMVGRS HGVFGEPITF GLVLALFADE IKRHLKALDL TMEFISVGAI
190 200 210 220 230 240
SGAMGNFAHA PLELEELACE FLGLKTANIS NQVIQRDRYA RLACDLALLA SSCEKIAVNI
250 260 270 280 290 300
RHLQRSEVYE VEEAFSTGQK GSSAMPHKRN PILSENITGL CRVIRSFTTP MLENVALWHE
310 320 330 340 350 360
RDMSHSSVER FALPDLFITS DFMLSRLNSV IKNLVVYPKN MLKNLALSGG LVFSQRVLLE
370 380 390 400 410 420
LPKKGLSREE SYSIVQENAM KIWEVLQQGA FKNTDENLFL NALLNDERLK KYLSEDEIKA
430
CFDYNYYTKN VGAIFKRVFE