P56218

PR
Gene name
map
Protein name
Methionine aminopeptidase
Names
MAP, MetAP, Peptidase M
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF0541
EC number
3.4.11.18: Aminopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-148 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P56218

Entry ID Method Resolution Chain Position Source
1WKM X-ray 230 A A/B 1-295 PDB
1XGM X-ray 280 A A/B 1-295 PDB
1XGN X-ray 290 A A/B 1-295 PDB
1XGO X-ray 350 A A 1-295 PDB
1XGS X-ray 175 A A/B 1-295 PDB
2DFI X-ray 210 A A/B 1-292 PDB
6LVH X-ray 320 A A 1-295 PDB
6M00 X-ray 320 A A 1-295 PDB
AF-P56218-F1 Predicted AlphaFoldDB

No variants for P56218

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P56218

No associated diseases with P56218

2 regional properties for P56218

Type Name Position InterPro Accession
domain Peptidase M24 5 - 286 IPR000994
binding_site Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site 77 - 93 IPR018349

Functions

Description
EC Number 3.4.11.18 Aminopeptidases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

2 GO annotations of biological process

Name Definition
protein initiator methionine removal The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDTEKLMKAG EIAKKVREKA IKLARPGMLL LELAESIEKM IMELGGKPAF PVNLSINEIA
70 80 90 100 110 120
AHYTPYKGDT TVLKEGDYLK IDVGVHIDGF IADTAVTVRV GMEEDELMEA AKEALNAAIS
130 140 150 160 170 180
VARAGVEIKE LGKAIENEIR KRGFKPIVNL SGHKIERYKL HAGISIPNIY RPHDNYVLKE
190 200 210 220 230 240
GDVFAIEPFA TIGAGQVIEV PPTLIYMYVR DVPVRVAQAR FLLAKIKREY GTLPFAYRWL
250 260 270 280 290
QNDMPEGQLK LALKTLEKAG AIYGYPVLKE IRNGIVAQFE HTIIVEKDSV IVTTE