P55202

PR
Gene name
npr2
Protein name
Atrial natriuretic peptide receptor 2
Names
Atrial natriuretic peptide receptor type B, ANP-B, ANPR-B, NPR-B, Guanylate cyclase B, GC-B
Species
Anguilla japonica (Japanese eel)
KEGG Pathway
EC number
4.6.1.2: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

808-879 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P55202

Entry ID Method Resolution Chain Position Source
AF-P55202-F1 Predicted AlphaFoldDB

No variants for P55202

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P55202

No associated diseases with P55202

5 regional properties for P55202

Type Name Position InterPro Accession
domain Protein kinase domain 517 - 790 IPR000719
domain Adenylyl cyclase class-3/4/guanylyl cyclase 829 - 1041 IPR001054
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 548 - 787 IPR001245
domain Receptor, ligand binding region 47 - 402 IPR001828
conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site 972 - 995 IPR018297

Functions

Description
EC Number 4.6.1.2 Phosphorus-oxygen lyases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
natriuretic peptide receptor activity Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

4 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
protein phosphorylation The process of introducing a phosphate group on to a protein.
receptor guanylyl cyclase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDLGHSLFVV FTCFLMARCR TEIGKNITVV VMLPDNHLKY SFAFPRVFPA IRMAHDDIQK
70 80 90 100 110 120
KGKLLRGYTI NLLNHSTESQ GAGCSESQAQ IMAVDTKLYE KPDAFFGPGC VYSVASVGRF
130 140 150 160 170 180
VNHWKLPLIT AWAPAFGFDS KEEYRTIVRT GLSTTKLGEF AHYLHSHFNW TTRAFMLFHD
190 200 210 220 230 240
LKVDDRPYYF ISEGVFLVLR RENITVEAVP YDDQKNSDYR EMISSLKSNG RIVYICGPLD
250 260 270 280 290 300
TFLEFMRIFQ NEGLPPEDYA IFYLDMFAKS ILDKDYKPWE SSDINWTDPI KLFKSVFVIT
310 320 330 340 350 360
AKEPDNPEYK AFQRELHARA KQEFSVQLEP SLEDIIAGCF YDGFMLYAQA LNETLAEGGS
370 380 390 400 410 420
QNDGINITQK MQNRRFWGVT GLVSTDKNND RDIDFNLWAM TNHKTGQYGI VAYYNGTNKE
430 440 450 460 470 480
IVWSETEKIQ WPKGSPPLDN PPCVFSMDEP FCNEDQLPVL GIVAVGSGLA LIIFGISSFL
490 500 510 520 530 540
IYRKLKLEKE LAGMLWRIRW EELQFESPNK YHKCAGSRLT ISQRGSSYGS LITAHGKYQL
550 560 570 580 590 600
FAKTGYFKGN LVAIKHVNKK RIELTRQVLF ELKHMRDVQF NHLTRFIGAC IDPPNICIVT
610 620 630 640 650 660
EYCPRGSLQD ILENESINLD WMFRYSLIND IVKGMNFLHN SYIGSHGNLK SSNCVVDSRF
670 680 690 700 710 720
VLKITDYGLA SFRSSCENED SHALYAKKLW TAPELLIYDR HPPQGTQKGD VYSFGIILQE
730 740 750 760 770 780
IALRNGPFYV DGMDLSPKEI VQKVRNGQKP YFRPTTDTSC HSEELSILME GCWAEDPADR
790 800 810 820 830 840
PDFSYIKIFV MKLNKEGSTS ILNNLLSRME QYANNLENLV EERTQAYLEE KRKAENLLYQ
850 860 870 880 890 900
ILPHSVAEQL KRGETVQAEA FDSVTIYFSD IVGFTSMSAE STPLQVVTLL NDLYTCFDAI
910 920 930 940 950 960
IDNFDVYKVE TIGDAYMVVS DSQSRNGKLH AREIAGMSLA LLEQVKTFKI RHRPNDQLRL
970 980 990 1000 1010 1020
RIGIHTGPVC AGVVGLKMPR YCLFGDTVNT ASRMESNGEA LKIHLSSATK EVLDEFGYFD
1030 1040
LQLRGDVEMK GKGKMRTYWL LGEKTDVYVI