P54964
Gene name |
REX2 (YNT20, YLR059C, L2159) |
Protein name |
Oligoribonuclease, mitochondrial |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR059C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P54964
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P54964-F1 | Predicted | AlphaFoldDB |
5 variants for P54964
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-260497 | 18 | L>F | No | SGRP | |
| s12-260221 | 110 | N>D | No | SGRP | |
| s12-260083 | 156 | V>I | No | SGRP | |
| s12-259767 | 261 | S>Y | No | SGRP | |
| s12-259763 | 262 | L>F | No | SGRP |
No associated diseases with P54964
1 regional properties for P54964
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Exonuclease, RNase T/DNA polymerase III | 54 - 236 | IPR013520 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| nucleic acid binding | Binding to a nucleic acid. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| mitochondrial genome maintenance | The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. |
| U4 snRNA 3'-end processing | Any process involved in forming the mature 3' end of a U4 snRNA molecule. |
| U5 snRNA 3'-end processing | Any process involved in forming the mature 3' end of a U5 snRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKWLLFPARI | VARTRPNLFS | LYRRSVSQYL | RPRTIQNLQS | MAQTPELKTK | LFKPLVWIDC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EMTGLDHVND | RIIEICCIIT | DGHLAPVKAA | DGQGDSHYES | VIHYGPEVMN | KMNEWCIEHH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GNSGLTAKVL | ASEKTLAQVE | DELLEYIQRY | IPDKNVGVLA | GNSVHMDRLF | MVREFPKVID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLFYRIVDVS | SIMEVARRHN | PALQARNPKK | EAAHTAYSDI | KESIAQLQWY | MDNYLKPPQE |
| 250 | 260 | ||||
| TESVESIGSE | QPESPSSSTS | SLKRQRTDF |