P54960

PR
Gene name
Protein name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Names
HMG-CoA reductase
Species
Blattella germanica (German cockroach) (Blatta germanica)
KEGG Pathway
EC number
1.1.1.34: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

203-272 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54960

Entry ID Method Resolution Chain Position Source
AF-P54960-F1 Predicted AlphaFoldDB

No variants for P54960

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54960

No associated diseases with P54960

4 regional properties for P54960

Type Name Position InterPro Accession
domain Sterol-sensing domain 59 - 218 IPR000731
conserved_site Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 614 - 628 IPR023076-1
conserved_site Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 770 - 777 IPR023076-2
conserved_site Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 824 - 837 IPR023076-3

Functions

Description
EC Number 1.1.1.34 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Endoplasmic reticulum membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
hydroxymethylglutaryl-CoA reductase (NADPH) activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

2 GO annotations of biological process

Name Definition
coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVGRLFRAHG QFCASHPWEV IVATLTLTVC MLTVDQRPLG LPPGWGHNCI TLEEYNAADM
70 80 90 100 110 120
IVMTLIRCVA VLYSYYQFCH LQKLGSKYIL GIAGLFTVFS SFVFSSSVIN FLGSDVSDLK
130 140 150 160 170 180
DALFFFLLLI DLSKATVLAQ FALSSRSQDE VKHNIARGIA MLGPTITLDT VVETLVIGVG
190 200 210 220 230 240
MLSGVRRLEV LCCFACMSVI VNYVVFMTFY PACLSLILEL SRSGESGRPA WHDKSLIIKA
250 260 270 280 290 300
LHEEDQKPNP VVQRVKVIMS AGLMLVHAHR WVRCLSIALW PDLTSLRYFC THCDTGVSYS
310 320 330 340 350 360
RWSFASEGEE LPTVKLVTGD SVVNSNSTDD AQLHYYIMRW LTVSADHIVI LILLLALAVK
370 380 390 400 410 420
FVFFETRDEL TTTRGMDGWV EVSSPVEHKY VQTEQPSCSA PEQPLEEPPA SNRSIDECLS
430 440 450 460 470 480
VCKSDVGAQA LSDCEVMALV TSGHIAGYQL EKVVRNPERG VGIRRQILTK TADLKDALDN
490 500 510 520 530 540
LPYKNYDYLK VMGACCENVI GYMPVPVGVA GPLNLDGRLV HVPLATTEGC LVASTNRGMR
550 560 570 580 590 600
ALMRCGVTSR IVADGMTRGP VVRFPNIDRA SEAMLWMQVP YNFEQIKKNF DSTSRFARLS
610 620 630 640 650 660
KIHIRVAGRH LFIRFIATTG DAMGMNMLSK GTEVALAYVQ QVYPDMEILS LSGNFCTDKK
670 680 690 700 710 720
PAAVNWIEGR GKSVVCEAIV PADIIKSVLK TSVQALMDVN ITKNLIGSAV AGSIGGFNAH
730 740 750 760 770 780
AANIVTAIFI ATGQDPAQNV GSSNCMTLME PWGEDGKDLY VSCTMPSIEI GTIGGGTVLP
790 800 810 820 830 840
PQAACLDMLG VRGANEMCPG ENANTLARIV CGTVLAGELS LMSALAAGHL VKSHMRHNRS
850
SVSTSGSEPS TPACKS