P54744

PR
Gene name
pknB (ML0016)
Protein name
Serine/threonine-protein kinase PknB
Names
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML0016
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

258-349 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54744

Entry ID Method Resolution Chain Position Source
AF-P54744-F1 Predicted AlphaFoldDB

No variants for P54744

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54744

No associated diseases with P54744

7 regional properties for P54744

Type Name Position InterPro Accession
domain Protein kinase domain 11 - 273 IPR000719
domain PASTA domain 352 - 418 IPR005543-1
domain PASTA domain 419 - 486 IPR005543-2
domain PASTA domain 487 - 553 IPR005543-3
domain PASTA domain 554 - 622 IPR005543-4
active_site Serine/threonine-protein kinase, active site 134 - 146 IPR008271
binding_site Protein kinase, ATP binding site 17 - 40 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTPPHLSDR YELGDILGFG GMSEVHLARD IRLHRDVAVK VLRADLARDP SFYLRFRREA
70 80 90 100 110 120
QNAAALNHPS IVAVYDTGEA ETSAGPLPYI VMEYVDGATL RDIVHTDGPM PPQQAIEIVA
130 140 150 160 170 180
DACQALNFSH QNGIIHRDVK PANIMISATN AVKVMDFGIA RAIADSTSVT QTAAVIGTAQ
190 200 210 220 230 240
YLSPEQARGD SVDARSDVYS LGCVLYEILT GEPPFIGDSP VSVAYQHVRE DPIPPSQRHE
250 260 270 280 290 300
GISVDLDAVV LKALAKNPEN RYQTAAEMRA DLIRVHSGQP PEAPKVLTDA DRSCLLSSGA
310 320 330 340 350 360
GNFGVPRTDA LSRQSLDETE SDGSIGRWVA VVAVLAVLTI AIVAAFNTFG GNTRDVQVPD
370 380 390 400 410 420
VRGQVSADAI SALQNRGFKT RTLQKPDSTI PPDHVISTEP GANASVGAGD EITINVSTGP
430 440 450 460 470 480
EQREVPDVSS LNYTDAVKKL TSSGFKSFKQ ANSPSTPELL GKVIGTNPSA NQTSAITNVI
490 500 510 520 530 540
TIIVGSGPET KQIPDVTGQI VEIAQKNLNV YGFTKFSQAS VDSPRPTGEV IGTNPPKDAT
550 560 570 580 590 600
VPVDSVIELQ VSKGNQFVMP DLSGMFWADA EPRLRALGWT GVLDKGPDVD AGGSQHNRVA
610 620
YQNPPAGAGV NRDGIITLKF GQ