P54743

PR
Gene name
pknA (ML0017)
Protein name
Serine/threonine-protein kinase PknA
Names
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML0017
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

258-437 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

158-182 (Activation loop from InterPro)

Target domain

13-272 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P54743

Entry ID Method Resolution Chain Position Source
AF-P54743-F1 Predicted AlphaFoldDB

No variants for P54743

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54743

No associated diseases with P54743

2 regional properties for P54743

Type Name Position InterPro Accession
domain Protein kinase domain 13 - 272 IPR000719
active_site Serine/threonine-protein kinase, active site 137 - 149 IPR008271

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSPRIGVMLS GRYRLHRLIA TGGMGQVWEA VDSRLGRRVA VKVLKGEFSS DPEFIERFRA
70 80 90 100 110 120
EARTTAMLNH PGIASVHDYG ESHMDGEGRT AYLVMELVNG EPLNSVLKRT GRLSLRHALD
130 140 150 160 170 180
MLEQTGRALQ IAHAAGLVHR DVKPGNILIT PTGQVKITDF GIAKAVDAAP VTQTGMVMGT
190 200 210 220 230 240
AQYIAPEQAL GHDATPASDV YSLGVIGYEV VSGKRPFTGD GALTVAMKHI KEPPPPLPAD
250 260 270 280 290 300
LPPNVRELIE ITLVKNPGMR YPSGGLFAEA VAAVRAGHRP PRPNQTPSSG RASPTTIPSS
310 320 330 340 350 360
TQARAAVACG TKTPAPRRSR PSTSGNRPPP ARNTFSSGQR ALLWAAGMLG ALAIIIAVLI
370 380 390 400 410 420
VINSYAGNEQ HQPPTPTVTD TGTPPATKTL SGFPAAYCEY RVNWTNHKEI SNSGLPKQAA
430
RAQLAGATDI SPVAGQT