P54690

PR
Gene name
Bcat1
Protein name
Branched-chain-amino-acid aminotransferase, cytosolic
Names
BCAT(c)
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29592
EC number
2.6.1.42: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54690

Entry ID Method Resolution Chain Position Source
AF-P54690-F1 Predicted AlphaFoldDB

No variants for P54690

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54690

No associated diseases with P54690

1 regional properties for P54690

Type Name Position InterPro Accession
conserved_site Aminotransferase, class IV, conserved site 282 - 316 IPR018300

Functions

Description
EC Number 2.6.1.42 Transaminases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

6 GO annotations of molecular function

Name Definition
branched-chain-amino-acid transaminase activity Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.
identical protein binding Binding to an identical protein or proteins.
L-isoleucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
L-leucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.
L-leucine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-valine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.

4 GO annotations of biological process

Name Definition
branched-chain amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
valine biosynthetic process The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAYLSRATAT LARQDCSNGC SASYAEEEEL EASTESYDEE GGSEASTQTF RAKDLIITKA
70 80 90 100 110 120
DVLKKKPDPS SLVFGASFTD HMLMVEWTSK YGWDKPHIKP FENLSIHPAA SVLHYAVELF
130 140 150 160 170 180
EGLKAFRGVD NKIRLFRPDL NMKRMCRSAV RTTLPEFDKE ELLQCVLQLI QLDREWVPYS
190 200 210 220 230 240
TSASLYIRPT FIGIEPSLGV KKPSKALLFV ILSPVGSYFS NGTFSPVSLW ANPKFVRSWK
250 260 270 280 290 300
GGTGDFKMGC NYGSSLLAQC EAAENGCHQV LWLYGKENRI TEVGTMNLFL YWINKDGEEE
310 320 330 340 350 360
LATPPLDGVI LPGVTRQSIL ELGEEWGEFK VCERHITMDD LSTALEENRV KEMFGSGTAC
370 380 390 400 410
VVCPVASILY KGQMLHIPTM ENGHKLSSRI MAKLTDIQYG RIKSEWTLEL P