P54665
Gene name |
CRK2 |
Protein name |
Cell division control protein 2 homolog 2 |
Names |
|
Species |
Trypanosoma brucei brucei |
KEGG Pathway |
|
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
186-209 (Activation loop from InterPro)
Target domain |
46-328 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P54665
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P54665-F1 | Predicted | AlphaFoldDB |
No variants for P54665
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P54665 | |||||
No associated diseases with P54665
1 regional properties for P54665
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Methyltransferase type 11 | 43 - 140 | IPR013216 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQVQVQEGQT | ACDGSLRPLP | SAGPASFVPR | SLRPAPLRGT | STPDRYSRIE | KVGEGSYGIV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YKCHDNFTGR | TVAMKRIPLI | VNDGGVPSTA | VREVSLLREL | NHPYVVRLLD | VVLHEAKLLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IFEYMEQDLQ | GMLKQRNTAF | VGGKLRRIMF | QLLLGLHECH | SRRFVHRDIK | PSNILIDRKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVVKLADFGL | GRAFRVPLQT | YTTEVMTLWY | RAPEVLLGDK | QYLPAVDVWS | MGCVFAELAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RRSLFAGDTA | INQLFSIFQL | LGTPTEATWR | GVTSLPHHNV | NFPRWTAKPL | RTAVPALDDD |
| 310 | 320 | 330 | 340 | ||
| GVDLLRRMLC | YNPRERITAY | EALQHSYFDE | VREEEVEKLM | RFNGA |