P54663

PR
Gene name
degS
Protein name
Signal transduction histidine-protein kinase/phosphatase DegS
Names
Species
Brevibacillus brevis (Bacillus brevis)
KEGG Pathway
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54663

Entry ID Method Resolution Chain Position Source
AF-P54663-F1 Predicted AlphaFoldDB

No variants for P54663

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54663

No associated diseases with P54663

4 regional properties for P54663

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 291 - 384 IPR003594
domain Histidine kinase domain 188 - 384 IPR005467
domain Sensor DegS 17 - 175 IPR008595
domain Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain 185 - 252 IPR011712

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPFKGLVVQV ADPQTLDKII DKTLDTVGKS REQIFEISEQ SRNEYVSLEQ ELQEVRMKVA
70 80 90 100 110 120
EIIDQSDRAE VHARFARNRL AEVSKQFHRY SNEEIRKVYE QANELQVKLA LLQQEEQQLR
130 140 150 160 170 180
DRRDAIERRL LNLKDTIERA EELVGQMTVV YNFLTGDLRQ VGEALEDARE KQAFGLQIIQ
190 200 210 220 230 240
AQEEERRKLS REIHDGPAQM MANVLLRSEL VERIYHDKGI DEALKEIRDL RKMVKSSLAE
250 260 270 280 290 300
VRRIIYDLRR MALDDLGLIP TLKKYVKTFE EHTGIFVDFK HIGKGERFPE HVEIALFRLV
310 320 330 340 350 360
QEALQNTRKH AKASHVHVKI EEQKTKFTVV IKDNGKGFDQ TEKKEGSFGL VGMKERVNML
370 380
KGQLVIRTKP NDGTTIIISI PITTEE