P54651

PR
Gene name
hspD (hsc90, hsp90, DDB_G0267400)
Protein name
Heat shock cognate 90 kDa protein
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0267400
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

488-563 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for P54651

Entry ID Method Resolution Chain Position Source
4XC0 X-ray 177 A A 1-223 PDB
4XCJ X-ray 175 A A 1-223 PDB
4XCL X-ray 121 A A 1-223 PDB
4XD8 X-ray 155 A A 1-223 PDB
4XDM X-ray 150 A A 1-223 PDB
4XE2 X-ray 120 A A 1-223 PDB
4XKA X-ray 200 A A 1-223 PDB
4XKK X-ray 270 A A 1-223 PDB
4XKO X-ray 246 A A 1-223 PDB
AF-P54651-F1 Predicted AlphaFoldDB

No variants for P54651

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54651

No associated diseases with P54651

3 regional properties for P54651

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 29 - 183 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 27 - 36 IPR019805
domain Heat shock protein Hsp90, N-terminal 7 - 208 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
unfolded protein binding Binding to an unfolded protein.

4 GO annotations of biological process

Name Definition
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of aggregation involved in sorocarp development Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAESQVERFT FQAEINQLMS LIINTFYSNK EVFLRELISN ASDALDKIRY QSLTDASVLE
70 80 90 100 110 120
SKTELEIKII PDKTAKTLTL IDSGIGMTKT DMVKNLGTIA RSGTKNFMEQ LQSGAADISM
130 140 150 160 170 180
IGQFGVGFYS AYLVADTVIV HSKNNDDEQY VWESSAGGEF TIALDHTEPL GRGTKIVLHM
190 200 210 220 230 240
KEDQLDYLDE TKIKNLVKKH SEFIQYPISL LTIKEKEVDE ETTAKEGEEE STDAKIEEIE
250 260 270 280 290 300
EEKEKKKVKV QEKEWDVLNK TKPLWTRNPS DVTKEEYNSF YKSISNDWEE PLAVKHFSVE
310 320 330 340 350 360
GQLEFKAILF VPKKAPFDLF ESKKKANNIK LYVKRVFIMD NCADIIPEYL NFVRGIVDSE
370 380 390 400 410 420
DLPLNISRET LQQNKILTVI RKNLVKKCIE LFNEIAENSE DYKKFYEAFS KNLKLGVHED
430 440 450 460 470 480
SQNREKFADL LRYQTSKSGD ELVTLKEYVG RMKEGQNEIY YITGESKKAV ENSPFIEGLK
490 500 510 520 530 540
KKNLEVIYMC DPIDEYAVQQ LKEYDGKKLV SITKEGLKLD ETEDEKKKAE QDKAANEELL
550 560 570 580 590 600
KQVKDVLGDK VEKVVLSTRL ANSPCVLVTS EYGWSANMER IMKAQALRDS SMSSYMSSKK
610 620 630 640 650 660
TLELNPDHPI VRDLAKKAAE KSKTFKDFVY LLYETALLTS GFSLDEPSSF ASRIHRMIKL
670 680 690
GLSIQDDSSA TTEESTNTTT SDDIPPLEEN DEPSEMEKVD