P54545

PR
Gene name
dinB1 (yqjH, BSU23870)
Protein name
DNA polymerase IV 1
Names
Pol IV 1
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU23870
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

360-414 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54545

Entry ID Method Resolution Chain Position Source
AF-P54545-F1 Predicted AlphaFoldDB

No variants for P54545

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54545

No associated diseases with P54545

3 regional properties for P54545

Type Name Position InterPro Accession
domain UmuC domain 8 - 189 IPR001126
domain DNA polymerase, Y-family, little finger domain 247 - 357 IPR017961
conserved_site DNA polymerase type-Y, HhH motif 173 - 201 IPR024728

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
magnesium ion binding Binding to a magnesium (Mg) ion.

3 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
error-prone translesion synthesis The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPGKSRIIFH IDMNSFYASV EMAYDPALRG KPVAVAGNVK ERKGIVVTCS YEARARGVKT
70 80 90 100 110 120
TMPVWQAKRH CPELIVLPPN FDRYRNSSRA MFTILREYTD LVEPVSIDEG YMDMTDTPYS
130 140 150 160 170 180
SRALETAKEI QSRLQKELLL PSSIGIAPNK FLAKMASDMK KPLGITILRK RQVPDILWPL
190 200 210 220 230 240
PVGEMHGVGK KTAEKLKGLG IHTIGELAAA DEHSLKRLLG INGPRLKNKA NGIHHAPVDP
250 260 270 280 290 300
ERIYEFKSVG NSSTLSHDSS DEEELLGVFR KLAASVSDRL QRKEVMASKL FIMIRYADWR
310 320 330 340 350 360
TITRSTTLRN PIDQKNDILK EAEHLFFKHW NKNPVRLLGI TGTDLVEKEQ AYKQLDLFSF
370 380 390 400 410
NEDAKDEPIQ QMMEKLNKKY GTKLIRKGAT LKKEESKTKG TSFNKDFFQD EKKS