P54544

PR
Gene name
misCB (yqjG, BSU23890)
Protein name
Membrane protein insertase MisCB
Names
Foldase YidC 1, Membrane integrase YidC 1, Membrane protein YidC 1
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU23890
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

60-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54544

Entry ID Method Resolution Chain Position Source
AF-P54544-F1 Predicted AlphaFoldDB

No variants for P54544

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54544

No associated diseases with P54544

2 regional properties for P54544

Type Name Position InterPro Accession
domain Membrane insertase YidC/Oxa/ALB, C-terminal 63 - 258 IPR028055
domain Membrane insertase YidC/ALB, C-terminal 64 - 258 IPR047196

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Found uniformly distributed in both the mother cell and forespore following sporulation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
membrane insertase activity Binds transmembrane domain-containing proteins and mediates their integration into a membrane.

2 GO annotations of biological process

Name Definition
protein insertion into membrane The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKTYQKLLA MGIFLIVLCS GNAAFAATNQ VGGLSNVGFF HDYLIEPFSA LLKGVAGLFH
70 80 90 100 110 120
GEYGLSIILV TIIVRIVVLP LFVNQFKKQR IFQEKMAVIK PQVDSIQVKL KKTKDPEKQK
130 140 150 160 170 180
ELQMEMMKLY QEHNINPLAM GCLPMLIQSP IMIGLYYAIR STPEIASHSF LWFSLGQSDI
190 200 210 220 230 240
LMSLSAGIMY FVQAYIAQKL SAKYSAVPQN PAAQQSAKLM VFIFPVMMTI FSLNVPAALP
250 260 270
LYWFTSGLFL TVQNIVLQMT HHKSKKTAAL TESVK