P54247

PR
Gene name
Protein name
Acetylcholine receptor non-alpha chain
Names
Species
Onchocerca volvulus
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

284-385 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54247

Entry ID Method Resolution Chain Position Source
AF-P54247-F1 Predicted AlphaFoldDB

No variants for P54247

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54247

No associated diseases with P54247

3 regional properties for P54247

Type Name Position InterPro Accession
domain Neurotransmitter-gated ion-channel transmembrane domain 202 - 421 IPR006029
domain Neurotransmitter-gated ion-channel ligand-binding domain 1 - 195 IPR006202
conserved_site Neurotransmitter-gated ion-channel, conserved site 89 - 103 IPR018000

Functions

Description
EC Number
Subcellular Localization
  • Postsynaptic cell membrane; Multi-pass membrane protein
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

2 GO annotations of molecular function

Name Definition
acetylcholine-gated cation-selective channel activity Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
IIDVHEIDQI MTCSVWLKQV WIDKKLSWNP EIYGGVSVLY VPYEMVWVPD IVLYNTVDSN
70 80 90 100 110 120
YNITISTKAT LRYDGQVTWD SPAIFKTLCQ IDVRWFPFDE QNCHFKFGSW TYTEDLLNLE
130 140 150 160 170 180
LLDSDARYEL EMNENGELNN ITIFEEGIDL SDYYPSVEWD IMSRIAKRRT KNYLTSFSDE
190 200 210 220 230 240
AFIDIIFYLE LRRKPLFYTV NLVFPCVGIS FLTIVAFYLP PRSGEKVTLC ILILVALTVF
250 260 270 280 290 300
YLLLKDIIPA TSIALPLFGK YLLFTMIMVS LSVLVTVISL NLHFRRPSTH RMPIWVKWLF
310 320 330 340 350 360
LRILPKILFM RRPTLIKVDE AVRRVADYRR GYNMIINRYE QKVNCDSCRN VNKRITQEIQ
370 380 390 400 410 420
KIYRSPHVIK AFENVCFIAQ LLKKKDREAM IDEDWKFVAR VLDRLFLLLF SIACFLGTIL
430
ILFQAPSLYD TRQAIN