P54221

PR
Gene name
serS (rrnAC2808)
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
KEGG Pathway
hma:rrnAC2808
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54221

Entry ID Method Resolution Chain Position Source
AF-P54221-F1 Predicted AlphaFoldDB

No variants for P54221

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54221

No associated diseases with P54221

3 regional properties for P54221

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 231 - 419 IPR002314
domain Aminoacyl-tRNA synthetase, class II 139 - 430 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 1 - 110 IPR015866

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSRQFVREH PETVRDAIER KGVTGVDLDE ILDIDEEWRE LKAEGDGLRQ ERNEVSSKIG
70 80 90 100 110 120
ELKQDGKDEE AQEAIDRSQE LKDELQDIEE RADELESQLE EALLELPNIP HESVPTGEGE
130 140 150 160 170 180
ADNVERYREG FDDLRDLPDE VVPHYDLGED LDLLDFERGA KVSGGGYQFV KGEGARLEHA
190 200 210 220 230 240
LIQFMLDVHR EQEYVDVLPP IPVNSDSMEG TGQLPKFAED AYRVGARQDD DYDSDDLWLL
250 260 270 280 290 300
PTAEVPVTNM YRGEILLDDD LPVKHQAFSP NFRREAGEHG TETRGYVRVH QFHKVELVNF
310 320 330 340 350 360
VRPENSYDRL ESLLDEAAEV LDRLELPYRV LDMCTGDMGF TQAKKYDIEV WAPGDDMEDG
370 380 390 400 410 420
PDRGGRWLEV SSVSNFEDFQ ARRAGLRYRP ERHESADYLH TLNGSGLAVP RVLVAIMEYY
430 440 450
QNDDGTITVP EPLRPYMGGQ EVIEGSEKIG ESAVGAGEKE