P53953
Gene name |
SFB2 (ISS1, YNL049C, N2505, YNL2505C) |
Protein name |
SED5-binding protein 2 |
Names |
SEC24-related protein 2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YNL049C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53953
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53953-F1 | Predicted | AlphaFoldDB |
19 variants for P53953
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s14-537861 | 18 | A>S | No | SGRP | |
| s14-537828 | 29 | S>P | No | SGRP | |
| s14-537807 | 36 | T>A | No | SGRP | |
| s14-537755 | 53 | T>I | No | SGRP | |
| s14-537638 | 92 | L>P | No | SGRP | |
| s14-537627 | 96 | I>V | No | SGRP | |
| s14-537553 | 120 | K>N | No | SGRP | |
| s14-537330 | 195 | V>I | No | SGRP | |
| s14-536990 | 308 | S>L | No | SGRP | |
| s14-536943 | 324 | N>D | No | SGRP | |
| s14-536843 | 357 | N>S | No | SGRP | |
| s14-536831 | 361 | T>K | No | SGRP | |
| s14-536807 | 369 | I>T | No | SGRP | |
| s14-536202 | 571 | T>A | No | SGRP | |
| s14-535982 | 644 | K>R | No | SGRP | |
| s14-535871 | 681 | P>Q | No | SGRP | |
| s14-535596 | 773 | D>H | No | SGRP | |
| s14-535581 | 778 | D>N | No | SGRP | |
| s14-535370 | 848 | V>A | No | SGRP |
No associated diseases with P53953
6 regional properties for P53953
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, Sec23/Sec24-type | 161 - 196 | IPR006895 |
| domain | Sec23/Sec24, trunk domain | 234 - 504 | IPR006896 |
| domain | Sec23/Sec24, helical domain | 603 - 705 | IPR006900 |
| domain | Gelsolin-like domain | 731 - 805 | IPR007123 |
| domain | Sec23/Sec24 beta-sandwich | 510 - 591 | IPR012990 |
| domain | Sec24-like, trunk domain | 234 - 508 | IPR041742 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| COPII vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. |
| endoplasmic reticulum exit site | An endoplasmic reticulum part at which COPII-coated vesicles are produced. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| signal sequence binding | Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| COPII-coated vesicle cargo loading | The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHHKKRVYP | QAQVPYIASM | PIVAEQQQSQ | QQIDQTAYAM | GNLQLNNRAN | SFTQLAQNQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPGSGKVVNQ | LYPVDLFTEL | PPPIRDLSLP | PLPITISQDN | IVTPSEYSNV | PYQYVRSTLK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVPKTNSLLK | KTKLPFAIVI | RPYLHLQDSD | NQVPLNTDGV | IVRCRRCRSY | MNPFVVFINQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GRKWQCNICR | FKNDVPFGFD | QNLQGAPINR | YERNEIKNSV | VDYLAPVEYS | VREPPPSVYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLLDVSQNAV | KNGLLATSAR | TILENIEFLP | NHDGRTRIAI | ICVDHSLHYF | YVPLDDDYEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SDEDDEESDG | EEEDEDEEEE | DVDNSETIQM | FDIGDLDEPF | LPMPSDELVV | PLKYCKNNLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLLKKIPEIF | QDTHSSKFAL | GPALKAASNL | IKSTGGKVEV | ISSTLPNTGI | GKLKKRSEQG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILNTPKESSQ | LLSCKDSFYK | TFTIECNKLQ | ITVDMFLASE | DYMDVATLSH | LGRFSGGQTH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FYPGFNATSL | NDVTKFTREL | SRHLSMDISM | EAVMRVRCST | GLRATSFFGH | FFNRSSDLCA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FSTMPRDQSY | LFGISIEDSL | MAEYCYLQVS | TLLTLNTGER | RIRVMTLALP | TSESAREVFA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SADQLAITDF | MTQNAVTKAL | NSSMYSARDF | ITKSLEDILN | AYKKEISMSN | INSVTSLNLC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ANLRMLPLLM | NGLSKHIALR | PGVVPSDYRA | SALNRLETEP | LHYLIKSIYP | TVYSLHDMPD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EVGLPDFEGK | TVLPEPINAT | ISLFERYGLY | LIDNSAELFL | WVGGDAVPEL | LIDVFNTDTI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SQIPVGKSEL | PLLNDSPFNE | RLRRIIGRIR | ENNDTITFQS | LYIIRGPSIN | EPANLNSEKD |
| 850 | 860 | 870 | |||
| MASLRLWVLS | TLVEDKVLNC | ASYREYLQSM | KTSINR |