AiPD: Autoinhibited Protein Database

P53801

Gene name	PTTG1IP (C21orf1, C21orf3)
Protein name	Pituitary tumor-transforming gene 1 protein-interacting protein
Names	Pituitary tumor-transforming gene protein-binding factor, PBF, PTTG-binding factor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:754
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-70 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P53801

Entry ID	Method	Resolution	Chain	Position	Source
AF-P53801-F1	Predicted				AlphaFoldDB

176 variants for P53801

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10062468 rs763255609	3	P>S		No	ClinGen ExAC gnomAD
rs370210322 CA10062467	4	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA410480580 rs1280553395	5	V>M		No	ClinGen TOPMed
CA321878238 rs1038628804	7	R>G		No	ClinGen TOPMed gnomAD
rs1369716074 CA410480568	7	R>P		No	ClinGen TOPMed gnomAD
CA410480563 rs1255369952	8	G>E		No	ClinGen TOPMed
rs908742208 CA410480565 CA321878221	8	G>R		No	ClinGen TOPMed gnomAD
rs11537965 CA321878216	9	P>Q		No	ClinGen Ensembl
CA321878213 rs971862134	10	T>K		No	ClinGen TOPMed
CA321878212 rs971862134	10	T>M		No	ClinGen TOPMed
CA410480548 rs1448177522	11	P>L		No	ClinGen TOPMed gnomAD
rs1245742750 CA410480541	12	Y>C		No	ClinGen gnomAD
CA410480542 rs1245742750	12	Y>S		No	ClinGen gnomAD
CA410480534 rs1327411181	13	W>*		No	ClinGen gnomAD
rs1189927329 CA410480500	18	G>C		No	ClinGen TOPMed gnomAD
rs1189927329 CA410480501	18	G>R		No	ClinGen TOPMed gnomAD
rs1189927329 CA410480502	18	G>S		No	ClinGen TOPMed gnomAD
rs561013989 CA321878211	19	G>C		No	ClinGen 1000Genomes gnomAD
CA410480467 rs1396290290	24	L>V		No	ClinGen TOPMed
rs1032260127 CA321878190	28	P>Q		No	ClinGen TOPMed gnomAD
rs1032260127 CA410480442	28	P>R		No	ClinGen TOPMed gnomAD
CA410480426 rs1194097777	31	A>T		No	ClinGen gnomAD
rs1231148132 CA410480419	32	A>E		No	ClinGen TOPMed gnomAD
CA410480417 rs1231148132	32	A>V		No	ClinGen TOPMed gnomAD
CA10062466 rs765018047	33	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs765018047 CA321878171	33	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA410480393 rs1342739908	36	P>H		No	ClinGen TOPMed
rs1342739908 CA410480391	36	P>L		No	ClinGen TOPMed
rs1254381457 CA410480394	36	P>S		No	ClinGen TOPMed
CA410480389 rs1197507806	37	G>R		No	ClinGen TOPMed
rs759424576 CA10062465	38	A>D		No	ClinGen ExAC gnomAD
rs759424576 CA410480381	38	A>G		No	ClinGen ExAC gnomAD
rs1314713889 CA410479879	39	A>G		No	ClinGen gnomAD
rs776585974 CA10062464	39	A>P		No	ClinGen ExAC TOPMed gnomAD
CA321871037 rs13047375	41	S>A		No	ClinGen Ensembl
CA410479850 rs1569325989	42	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA10062452 rs560234616	43	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	44	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1223504958 CA410479810	45	N>K		No	ClinGen gnomAD
CA10062451 rs764213246	49	E>D		No	ClinGen ExAC gnomAD
rs752927140 CA10062449	51	C>*		No	ClinGen ExAC gnomAD
CA10062450 COSM1414449 rs758698293 COSM1414450	51	C>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	51	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10062448 rs764966007	52	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1403413012 CA410479739	53	K>Q		No	ClinGen gnomAD
COSM246897 rs766373886 CA10062445 COSM246896	55	V>I	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs200693153	56	S>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs749467135 CA410479229	57	C>G		No	ClinGen ExAC gnomAD
CA10062406 rs749467135	57	C>R		No	ClinGen ExAC gnomAD
rs779842845 CA10062405	58	L>F		No	ClinGen ExAC gnomAD
CA410479211 rs1279222607	59	W>*		No	ClinGen gnomAD
CA10062404 rs755949360	59	W>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1363771602 CA410479217	59	W>R		No	ClinGen gnomAD
rs1473833237 CA410479199	61	N>S		No	ClinGen gnomAD
rs144668992 CA10062403	62	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144668992 RCV000892715 CA10062402	62	T>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA410479184 rs1415768310	63	N>K		No	ClinGen TOPMed
rs1443282615 CA410479181	64	K>E		No	ClinGen gnomAD
rs1258519182 CA410479178	64	K>R		No	ClinGen gnomAD
rs1485403923 CA410479169	65	A>G		No	ClinGen gnomAD
CA410479172 rs1203217552	65	A>S		No	ClinGen TOPMed gnomAD
CA410479174 rs1203217552	65	A>T		No	ClinGen TOPMed gnomAD
CA410479171 rs1485403923	65	A>V		No	ClinGen gnomAD
CA410479165 rs1261052873	66	C>Y		No	ClinGen gnomAD
CA10062399 rs763445809	67	L>P		No	ClinGen ExAC gnomAD
rs763445809 CA410479157	67	L>R		No	ClinGen ExAC gnomAD
CA410479159 rs751093743	67	L>V		No	ClinGen ExAC gnomAD
rs775235646 CA10062397	70	P>R		No	ClinGen ExAC gnomAD
rs572176295 CA321862569	71	V>A		No	ClinGen 1000Genomes
CA410479135 rs1341953457	71	V>I		No	ClinGen gnomAD
CA410479128 rs1444673682	72	T>S		No	ClinGen TOPMed
CA321862559 rs1017735492	73	S>G		No	ClinGen TOPMed
CA10062394 rs200698166	74	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10062391 rs188877011	77	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA10062392 rs188877011	77	P>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs749344323 CA10062389	80	L>I		No	ClinGen ExAC TOPMed gnomAD
CA10062388 rs780292790	81	C>Y		No	ClinGen ExAC gnomAD
CA10062387 rs756323234	83	L>S		No	ClinGen ExAC gnomAD
CA410479048 rs1157993302	85	S>P		No	ClinGen TOPMed gnomAD
CA321862473 rs995818281 COSM1414448	87	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA10062384 rs574813996	87	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs574813996 CA10062383	87	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA410479035 rs574813996	87	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	89	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410479024 rs1438536402	89	G>R		No	ClinGen TOPMed
CA410479018 rs1357807963	90	V>L		No	ClinGen gnomAD
rs867604734 CA321862458	91	C>F		No	ClinGen Ensembl
rs1249067188 CA410479000	92	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1176303433 CA410478997	93	V>M		No	ClinGen TOPMed
TCGA novel	94	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199732063 CA10062360 CA10062358	95	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA410477846 rs1569322088	96	E>K		No	ClinGen Ensembl
CA410477827 rs1433045193	97	A>E		No	ClinGen TOPMed gnomAD
CA410477825 rs1433045193	97	A>V		No	ClinGen TOPMed gnomAD
CA410477790 rs1231093139	100	I>T		No	ClinGen gnomAD
CA10062354 rs762122109	102	M>I		No	ClinGen ExAC gnomAD
rs367999727 CA10062355	102	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA10062353 rs138357182 COSM1414447	103	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA410477750 rs1485107726	104	V>I		No	ClinGen gnomAD
COSM76128 CA10062350 rs775551316	106	G>R	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs775551316 CA410477727 COSM1414446	106	G>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1369311357 CA410477708	108	T>P		No	ClinGen TOPMed
rs1369311357 CA410477704	108	T>S		No	ClinGen TOPMed
rs746151007 CA10062349	110	L>F		No	ClinGen ExAC TOPMed gnomAD
rs746151007 CA10062348	110	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1338778940 CA410477668	111	L>R		No	ClinGen TOPMed
rs11537962 CA410477675	111	L>V		No	ClinGen TOPMed
CA410477660 rs1212903526	112	G>D		No	ClinGen TOPMed
rs1292179885 CA410477641	114	A>T		No	ClinGen TOPMed
CA10062347 rs538543975	115	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1466982717 CA410477621	115	I>M		No	ClinGen TOPMed
rs1309876073 CA410477623	115	I>S		No	ClinGen TOPMed gnomAD
CA10062346 rs538543975	115	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs11537967 CA321858066	118	C>S		No	ClinGen Ensembl
rs1190037139 CA410477558	120	C>Y		No	ClinGen TOPMed
CA410477544 rs375347383	121	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10062344 rs375347383	121	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs552229746 CA10062338	123	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA410477510 rs1392652973	123	R>S		No	ClinGen TOPMed
CA10062339 rs552229746	123	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA321858044 rs991633787	124	K>E		No	ClinGen TOPMed
CA410477495 rs1472852030	125	R>G		No	ClinGen TOPMed gnomAD
CA321858037 rs934547595	125	R>K		No	ClinGen Ensembl
rs1413553607 CA410477480	126	S>N		No	ClinGen gnomAD
rs141726521 CA10062334	127	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147066771 CA10062336	127	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10062332 rs751876287	129	P>L		No	ClinGen ExAC gnomAD
rs751876287 CA410477442	129	P>Q		No	ClinGen ExAC gnomAD
CA321858019 rs372394942	129	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA gnomAD
CA10062330 rs763474762	130	D>E		No	ClinGen ExAC gnomAD
CA10062329 rs753162911	131	R>K		No	ClinGen ExAC gnomAD
CA10062328 rs765702233	132	S>I		No	ClinGen ExAC TOPMed gnomAD
CA410477403 rs1601245128	132	S>R		No	ClinGen Ensembl
rs149230223 CA321857998	133	E>K		No	ClinGen ESP TOPMed gnomAD
CA10062327 rs759582287	135	K>T		No	ClinGen ExAC gnomAD
rs776756544 CA10062326	136	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1190645296 CA410477342	137	M>T		No	ClinGen TOPMed
CA10062324 rs760882023	137	M>V		No	ClinGen ExAC gnomAD
rs558171606 CA321857987	138	R>C		No	ClinGen gnomAD
rs145408959 CA10062322	138	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA10062320 rs747925634	140	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10062321 COSM1414444 rs374480622	140	R>W	large_intestine Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA321857971 rs200868733	141	E>K		No	ClinGen 1000Genomes gnomAD
CA10062319 rs774483315	142	E>K		No	ClinGen ExAC gnomAD
CA410477275 rs1569321923	143	R>G		No	ClinGen Ensembl
CA410477269 rs1164783650	143	R>T		No	ClinGen TOPMed
rs143122508 CA10062318 COSM1641474	144	R>Q	Variant assessed as Somatic; 0.0 impact. stomach [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA10062316 rs779552781	146	R>Q		No	ClinGen ExAC gnomAD
COSM1414443 rs748818985 CA10062317	146	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA321857960 rs965755144	147	Q>E		No	ClinGen Ensembl
TCGA novel	148	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10062315 rs77285520	148	E>G		No	ClinGen ExAC gnomAD
CA10062314 rs112131899	149	E>G		No	ClinGen ExAC
rs778141805 CA10062313	150	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA410477188 rs1230258589	150	R>W		No	ClinGen TOPMed gnomAD
CA10062281 rs763902068	152	A>V		No	ClinGen ExAC gnomAD
rs775537697 CA10062279	154	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1209628724 CA410477019	156	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	156	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410477017 rs1251116720	157	R>G		No	ClinGen gnomAD
CA410476979 rs1206162158	159	D>E		No	ClinGen gnomAD
CA410476977 rs1281141606	160	E>K		No	ClinGen gnomAD
rs1220353202 CA410476953	161	I>N		No	ClinGen gnomAD
CA410476944 rs1296305201	162	R>K		No	ClinGen gnomAD
rs1399956835 TCGA novel CA410476924	163	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
TCGA novel	164	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA749760860 rs1444046541	165	Y>*		No	ClinGen TOPMed
rs769596172 CA10062277	165	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1199997389 CA410475874	166	G>V		No	ClinGen TOPMed
rs1229687138 CA410475858	167	L>P		No	ClinGen gnomAD
rs1311534111 CA410475827	168	F>L		No	ClinGen gnomAD
CA410475823 rs1330769940	169	K>E		No	ClinGen Ensembl
COSM3939526 CA10062253 COSM3939525 rs772953103	171	E>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10062252 rs771614983	173	P>L		No	ClinGen ExAC TOPMed gnomAD
CA410475724 rs1484650510	175	A>P		No	ClinGen TOPMed
rs1160073142 CA410475647	179	N>I		No	ClinGen gnomAD

No associated diseases with P53801

1 regional properties for P53801

Type	Name	Position	InterPro Accession
domain	PSI domain	39 - 92	IPR016201

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type I membrane protein Cytoplasm Nucleus	According to PubMed:10781616, it is found in the cytoplasm and the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
p53 binding	Binding to one of the p53 family of proteins.

4 GO annotations of biological process

Name	Definition
negative regulation of DNA damage response, signal transduction by p53 class mediator	Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.
positive regulation of protein ubiquitination	Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
protein import into nucleus	The directed movement of a protein from the cytoplasm to the nucleus.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAPGVARGPT	PYWRLRLGGA	ALLLLLIPVA	AAQEPPGAAC	SQNTNKTCEE	CLKNVSCLWC
70	80	90	100	110	120
NTNKACLDYP	VTSVLPPASL	CKLSSARWGV	CWVNFEALII	TMSVVGGTLL	LGIAICCCCC
130	140	150	160	170
CRRKRSRKPD	RSEEKAMRER	EERRIRQEER	RAEMKTRHDE	IRKKYGLFKE	ENPYARFENN